Search Results
Overview
| Uniprot ID | A0A8I6GHD3 |
|---|---|
| Protein Name | T-complex protein 1 subunit epsilon |
| Gene Name | Cct5 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 203 | IKGVIVDKDFSHPQM |
| 236 | PKPKTKHKLDVTSVE |
| 246 | VTSVEDYKALQKYEK |
| 485 | IETLIGKKQQISLAT |
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia
Protein Sequence
10
MWSSLGSHIM
20
AAKAVANTMR
30
TSLGPNGLDK
40
MMVDKDGDVT
50
VTNDGATILS
60
MMDVDHQIAK
70
LMVELSKSQD
80
DEIGDGTTGV
90
VVLAGALLEE
100
AEQLLDRGIH
110
PIRIADGYEQ
120
AARIAIQHLD
130
KISDNVLVDI
140
NNPEPLIQTA
150
KTTLGSKVVN
160
SCHRQMAEIA
170
VNAVLTVADM
180
ERRDVDFELI
190
KVEGKVGGRL
200
EDTKLIKGVI
210
VDKDFSHPQM
220
PKEVLNAKIA
230
ILTCPFEPPK
240
PKTKHKLDVT
250
SVEDYKALQK
260
YEKEKFEEMI
270
AQIKETGANL
280
AICQWGFDDE
290
ANHLLLQNGL
300
PAVRWVGGPE
310
IELIAIATGG
320
RIVPRFSELT
330
SEKLGFAGVV
340
REISFGTTKD
350
KMLVIEQCKN
360
SRAVTIFIRG
370
GNKMIIEEAK
380
RSLHDALCVI
390
RNLIRDNRVV
400
YGGGAAEISC
410
ALAVSQEADK
420
CPTLEQYAMR
430
AFADALEVIP
440
MALSENSGMN
450
PIQTMTEVRA
460
RQVKESNPAL
470
GIDCLHKGSN
480
DMQYQHVIET
490
LIGKKQQISL
500
ATQMVRMILK
510
IDDIRKPGES
EE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005832 | chaperonin-containing T-complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0140662 | ATP-dependent protein folding chaperone |
| Molecular Function | GO:0051082 | unfolded protein binding |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.