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Overview

Uniprot IDA0A8I6GIG4
Protein NameFerritin
Gene NameFtl1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
144 KEVKLIKKMGNHLTN

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation

Protein Sequence

10 MTSQIRQNYS 20 TEVEAAVNRP 30 VNLHLRASYT 40 YLSLGFFFDR 50 DDVALEGVGH 60 FFRELAEEKR 70 EGAERLLKLQ 80 NERGGRALFQ 90 DVRKPSQDEW 100 GKTLEAMEAA 110 LALEKNLNQA 120 LLDLHALGSA 130 RTDPHLCDFL 140 ESHFLDKEVK 150 LIKKMGNHLT 160 NLRRVAGPQP 170 AQTGVAQASL 180 GEYLFERLTL KHD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0044754 autolysosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0031410 cytoplasmic vesicle
Molecular Function GO:0008199 ferric iron binding
Molecular Function GO:0008198 ferrous iron binding
Biological Process GO:0006879 intracellular iron ion homeostasis
Biological Process GO:0006826 iron ion transport

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.