Overview
| Uniprot ID | A0A8I6GIW5 |
|---|
| Protein Name | F-actin-capping protein subunit beta |
|---|
| Gene Name | Capzb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 223 |
LNEIYFGKTKDIVNG |
| 242 |
DAIPDNHKFKQLQRE |
| 45 |
ARDKVVGKDYLLCDY |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules
Protein Sequence
10
MRRLPPQQIE
20
KNLSDLIDLV
30
PSLCEDLLSS
40
VDQPLKIARD
50
KVVGKDYLLC
60
DYNRDGDSYR
70
SPWSNKYDPP
80
LEDGAMPSAR
90
LRKLEVEANN
100
AFDQYRDLYF
110
EGGVSSVYLW
120
DLDHGFAGVI
130
LIKKAGDGSK
140
KIKGCWDSIH
150
VVEVQEKSSG
160
RTAHYKLTST
170
VMLWLQTNKS
180
GSGTMNLGGS
190
LTRQMEKDET
200
VSDCSPHIAN
210
IGRLVEDMEN
220
KIRSTLNEIY
230
FGKTKDIVNG
240
LRSLDAIPDN
250
HKFKQLQREL
260
SQVLTQRQVY
IQPDN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008290 |
F-actin capping protein complex |
| Cellular Component |
GO:0030017 |
sarcomere |
| Molecular Function |
GO:0003779 |
actin binding |
| Biological Process |
GO:0030036 |
actin cytoskeleton organization |
| Biological Process |
GO:0051016 |
barbed-end actin filament capping |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.