Search Results

Overview

Uniprot ID	A0A8I6GK55
Protein Name	Calpastatin
Gene Name	Cast
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
283	KSTGESSKAQSAGVT

Function

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue

Protein Sequence

10 MAFANWWYKT 20 HVNEKNIGSS 30 SKPAEKKGSD 40 EVTASSAATG 50 TSPRMSTTGA 60 KAVKIESEKS 70 QSSEPPVIHE 80 KKPKGKPKEG 90 SEPQTLPKHA 100 SDTGSKHAHK 110 EKALSRSNEQ 120 IVSEKSSESK 130 TKFQDAPSAD 140 GESVAGGVTV 150 ATASDKVVVK 160 KKEKKSLTPT 170 LPMESTLNKL 180 SDKSGVNAAL 190 DDLIDTLGEC 200 EDTNKDDPPY 210 TGPVVLDPMD 220 STYLEALGIK 230 EGTIPPEYRK 240 LLEKNEAITG 250 PLPDSPKPMG 260 IDHAIDALSS 270 DFTCSSPTGK 280 QTEKEKSTGE 290 SSKAQSAGVT 300 RSAVPPQEKK 310 RKVEEEVMND 320 QALQALSDSL 330 GTRQPDPQSH 340 LRQAKQVKEA 350 KAKEERQEKC 360 GEDEDTVPAE 370 YRLKPAKDKD 380 GKPLLPEPEE 390 TSKCLSESEL 400 IGELSADFVQ 410 PTYQEKPSMP 420 AAKIKKGVVP 430 DDAVETLARS 440 LGTRKEDPED 450 EKSLVDKVKE 460 KAKEEDHEKL 470 GEKEETIPPD 480 YRLEIVKDKD 490 GKPLLPKEAE 500 EQLPPLSDDF 510 LLDALSQDFS 520 SPANILSLGF 530 EDAKLSAAVS 540 ETVSQVPAPS 550 NHTAAPPPGT 560 ERRDKELDDA 570 LDELSDSLGQ 580 RQPDPDENKP 590 LDDKVKEKIK 600 AEHSEKLGER 610 DDTIPPEYRH 620 LLDNDGKDKP 630 EKPLTKNTEK 640 PGQDQDPIDA 650 LSEDLDSCPP 660 TTETSQNTTK 670 EKGKKTSSSK 680 ASKNEEKTKD 690 SSKKTEEVPK PKVDEDAT

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.