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Overview

Uniprot IDA0A8I6GKB1
Protein NameMolybdenum cofactor biosynthesis protein 1
Gene NameMocs1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
520 LLGPKAFKLVQQNQL

Function

Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP

Protein Sequence

10 MAARPASRML 20 RQLLRSNVRS 30 CSSGAPMTQP 40 RPGEPSRPTR 50 EGLSMRLQFL 60 QEHAAPFSAF 70 LTDSFGRQHS 80 YLRISLTEKC 90 NLRCRYCMPE 100 EGVSLTPKAD 110 LLTTEEILTL 120 ARLFVKEGVD 130 KIRLTGGEPL 140 IRPDVVDIVA 150 RLHQLEGLRT 160 IGVTTNGINL 170 ARLLPSLQQA 180 GLSAVNVSLD 190 TLVPAKFEFI 200 VRRKGFHKVM 210 EGIHKAIELG 220 YKPVKVNCVV 230 MRGLNEDELL 240 DFVALTEGLP 250 LDVRFIEYMP 260 FDGNKWNFKK 270 MVSYKEMLDA 280 IRQRWPGLEK 290 LPEEDSSTAK 300 AFKIPGFQGQ 310 ISFITSMSEH 320 FCGTCNRLRI 330 TADGNLKVCL 340 FGNSEVSLRD 350 HLRAGASEEE 360 LLRIIGVAVG 370 RKKRQHAGMF 380 NIAQMKNRPM 390 ILIGVLLMLQ 400 DSPPASWSTL 410 SWDPLHVRNP 420 GAKQCLSDQM 430 ATLWKRHSVP 440 MALPLSQQCL 450 GSGSPQRHYS 460 SYPDPDTHPK 470 CLSTGSRAPD 480 VPSGPGPTSD 490 QLTHVDSAGR 500 ATMVDVGGKP 510 ETERVAVASA 520 MVLLGPKAFK 530 LVQQNQLKKG 540 DALVVAQLAG 550 VQAAKLTSQL 560 IPLCHHVALS 570 HVQVHLELDS 580 TRHAVLIQVS 590 CRARGPTGVE 600 MEALTSAAMA 610 ALTVYDMCKA 620 VSRDIVVTEV 630 KLISKTGGQR GDFHRT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005759 mitochondrial matrix
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
Molecular Function GO:0061799 cyclic pyranopterin monophosphate synthase activity
Molecular Function GO:0061798 GTP 3',8'-cyclase activity
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:1904047 S-adenosyl-L-methionine binding
Biological Process GO:0006777 Mo-molybdopterin cofactor biosynthetic process
Biological Process GO:0032324 molybdopterin cofactor biosynthetic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.