Overview
| Uniprot ID | A0A8I6GKS0 |
|---|
| Protein Name | Peptidyl-prolyl cis-trans isomerase D |
|---|
| Gene Name | Ppid |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 253 |
LRYLDSSKAVIEKAD |
| 258 |
SSKAVIEKADVSRLQ |
| 309 |
NTKALYRKAQGWQGL |
| 337 |
QEIAPGDKAIQAELL |
Function
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity region. Involved in regulation of UV radiation-induced apoptosis
Protein Sequence
10
MSHPSPAGKP
20
SNSKNPRVFF
30
DVDIGGERVG
40
RIVLELFADI
50
VPKTAENFRA
60
LCTGEKGTGP
70
TTGKPLHFKG
80
CPFHRIIKKF
90
MIQGGDFSNQ
100
NGTGGESIYG
110
EKFEDENFHY
120
KGLLSMANAG
130
PNTNGSQFFI
140
TTVPTPHLDG
150
KHVVFGQVIK
160
GLGVARMLEN
170
VEVNGEKPAK
180
LCVIAECGEL
190
KEGDEWGIFP
200
KDGSGDSHPD
210
FPEDADIDLK
220
DVDKILLISE
230
DLKNIGNTFF
240
KSQNWEMAIK
250
KYAKVLRYLD
260
SSKAVIEKAD
270
VSRLQPIALS
280
CVLNIGACKL
290
KMSNWQGAID
300
SCLEALEMDP
310
SNTKALYRKA
320
QGWQGLKEYD
330
QALADLKKAQ
340
EIAPGDKAIQ
350
AELLKVKQMI
360
KAQKDKEKAV
YAKMFA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0033218 |
amide binding |
| Molecular Function |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
| Biological Process |
GO:0006457 |
protein folding |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.