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Overview

Uniprot IDA0A8I6GL05
Protein NameSodium channel protein
Gene NameScn2a
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1837 ITTTLKRKQEEVSAI

Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient

Protein Sequence

10 MARSVLVPPG 20 PDSFRFFTRE 30 SLAAIEQRIA 40 EEKAKRPKQE 50 RKDEDDENGP 60 KPNSDLEAGK 70 SLPFIYGDIP 80 PEMVSEPLED 90 LDPYYINKKT 100 FIVLNKGKAI 110 SRFSATSALY 120 ILTPFNPIRK 130 LAIKILVHSY 140 PFDSYNPPDW 150 TKNVEYTFTG 160 IYTFESLIKI 170 LARGFCLEDF 180 TFLRDPWNWL 190 DFTVITFAYV 200 TEFVDLGNVS 210 ALRTFRVLRA 220 LKTISVIPGL 230 KTIVGALIQS 240 VKKLSDVMIL 250 TVFCLSVFAL 260 IGLQLFMGNL 270 RNKCLQWPPD 280 NSTFEINITS 290 FFNNSLDWNG 300 TAFNRTVNMF 310 NWDEYIEDKS 320 HFYFLEGQND 330 ALLCGNSSDA 340 GQCPEGYICV 350 KAGRNPNYGY 360 TSFDTFSWAF 370 LSLFRLMTQD 380 FWENLYQLTL 390 RAAGKTYMIF 400 FVLVIFLGSF 410 YLINLILAVV 420 AMAYEEQNQA 430 TLEEAEQKEA 440 EFQQMLEQLK 450 KQQEEAQAAA 460 AAASAESRDF 470 SGAGGIGVFS 480 ESSSVASKLS 490 SKSEKELKNR 500 RKKKKQKEQA 510 GEEEKEDAVR 520 KSASEDSIRK 530 KGFRFSLEGS 540 RLTYEKRFSS 550 PHQSLLSIRG 560 SLFSPRRNSR 570 ASLFSFKGRV 580 KDIGSENDFA 590 DDEHSTFEDN 600 DSRRDSLFVP 610 HRHGERRPSN 620 GTTTETEIRK 630 RRSSSYHVSM 640 DLLEDPSRQR 650 AMSMASILTN 660 TMEELEESRQ 670 KCPPCWYKFA 680 NMCLIWDCCK 690 PWLKVKHVVN 700 LVVMDPFVDL 710 AITICIVLNT 720 LFMAMEHYPM 730 TEQFSSVLSV 740 GNLVFTGIFT 750 AEMFLKIIAM 760 DPYYYFQEGW 770 NIFDGFIVSL 780 SLMELGLANV 790 EGLSVLRSFR 800 LLRVFKLAKS 810 WPTLNMLIKI 820 IGNSVGALGN 830 LTLVLAIIVF 840 IFAVVGMQLF 850 GKSYKECVCK 860 ISNDCELPRW 870 HMHDFFHSFL 880 IVFRVLCGEW 890 IETMWDCMEV 900 AGQTMCLTVF 910 MMVMVIGNLV 920 VLNLFLALLL 930 SSFSSDNLAA 940 TDDDNEMNNL 950 QIAVGRMQKG 960 IDFVKRKIRE 970 FIQKAFVRKQ 980 KALDEIKPLE 990 DLNNKKDSCI 1000 SNHTTIEIGK 1010 DLNYLKDGNG 1020 TTSGIGSSVE 1030 KYVVDESDYM 1040 SFINNPSLTV 1050 TVPIALGESD 1060 FENLNTEEFS 1070 SESDMEESKE 1080 KLNATSSSEG 1090 STVDIGAPAE 1100 GEQPEAEPEE 1110 SLEPEASFSC 1120 LSIFPCCQIS 1130 IEEGKGKLWW 1140 NLRKTCYKIV 1150 EHNWFETFIV 1160 FMILLSSGAL 1170 AFEDIYIEQR 1180 KTIKTMLEYA 1190 DKVFTYIFIL 1200 EMLLKWVAYG 1210 FQMYFTNAWC 1220 WLDFLIVDVS 1230 LVSLTANALG 1240 YSELGAIKSL 1250 RTLRALRPLR 1260 ALSRFEGMRV 1270 VVNALLGAIP 1280 SIMNVLLVCL 1290 IFWLIFSIMG 1300 VNLFAGKFYH 1310 CINYTTGEMF 1320 DVSVVNNYSE 1330 CQALIESNQT 1340 ARWKNVKVNF 1350 DNVGLGYLSL 1360 LQVATFKGWM 1370 DIMYAAVDSR 1380 NVKLQPKYED 1390 NLYMYLYFVI 1400 FIIFGSFFTL 1410 NLFIGVIIDN 1420 FNQQKKKMSQ 1430 DIFMTEEQKK 1440 YYNAMKKLGS 1450 KKPQKPIPRP 1460 ANKFQGMVFD 1470 FVTKQVFDIS 1480 IMILICLNMV 1490 TMMVETDDQS 1500 QEMTNILYWI 1510 NLVFIVLFTG 1520 ECVLKLISLR 1530 HYYFTIGWNI 1540 FDFVVVILSI 1550 VGMFLAELIE 1560 KYFVSPTLFR 1570 VIRLARIGRI 1580 LRLIKGAKGI 1590 RTLLFALMMS 1600 LPALFNIGLL 1610 LFLVMFIYAI 1620 FGMSNFAYVK 1630 REVGIDDMFN 1640 FETFGNSMIC 1650 LFQITTSAGW 1660 DGLLAPILNS 1670 GPPDCDPEKD 1680 HPGSSVKGDC 1690 GNPSVGIFFF 1700 VSYIIISFLV 1710 VVNMYIAVIL 1720 ENFSVATEES 1730 AEPLSEDDFE 1740 MFYEVWEKFD 1750 PDATQFIEFC 1760 KLSDFAAALD 1770 PPLLIAKPNK 1780 VQLIAMDLPM 1790 VSGDRIHCLD 1800 ILFAFTKRVL 1810 GESGEMDALR 1820 IQMEERFMAS 1830 NPSKVSYEPI 1840 TTTLKRKQEE 1850 VSAIVIQRAY 1860 RRYLLKQKVK 1870 KVSSIYKKDK 1880 GKEDEGTPIK 1890 EDIITDKLNE 1900 NSTPEKTDVT 1910 PSTTSPPSYD 1920 SVTKPEKEKF 1930 EKDKSEKEDK GKDIRESKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001518 voltage-gated sodium channel complex
Molecular Function GO:0005248 voltage-gated sodium channel activity

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.