Search Results
Overview
| Uniprot ID | A0A8I6GLE7 |
|---|---|
| Protein Name | T-complex protein 1 subunit beta |
| Gene Name | Cct2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 187 | SKLLTHHKDHFTKLA |
| 202 | VEAVLRLKGSGNLEA |
| 214 | LEAIHVIKKLGGSLA |
| 259 | NTGMDTDKIKIFGSR |
| 274 | VRVDSTAKVAEIEHA |
| 283 | AEIEHAEKEKMKEKV |
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia
Protein Sequence
10
MPSSGVSEHS
20
NKASLSLAPV
30
NIFKAGADEE
40
RAETARLSSF
50
IGAIAIGDLV
60
KSTLGPKGMD
70
KILLSSGRDA
80
SLMVTNDGAT
90
ILKNIGVDNP
100
AAKVLVDMSR
110
VQDDEVGDGT
120
TSVTVLAAEL
130
LREAESLIAK
140
KIHPQTIIAG
150
WREATKAARE
160
ALLSSAVDHG
170
SDEVKFWQDL
180
MNIAGTTLSS
190
KLLTHHKDHF
200
TKLAVEAVLR
210
LKGSGNLEAI
220
HVIKKLGGSL
230
ADSYLDEGFL
240
LDKKIGVNQP
250
KRIENAKILI
260
ANTGMDTDKI
270
KIFGSRVRVD
280
STAKVAEIEH
290
AEKEKMKEKV
300
ERILKHGINC
310
FINRQLIYNY
320
PEQLFGAAGV
330
MAIEHADFAG
340
VERLALVTGG
350
EIASTFDHPE
360
LVKLGSCKLI
370
EEVMIGEDKL
380
IHFSGVALGE
390
ACTIVLRGAT
400
QQILDEAERS
410
LHDALCVLAQ
420
TVKDPRTVYG
430
GGCSEMLMAH
440
AVTMLASRTP
450
GKEAVAMESF
460
AKALRMLPTI
470
IADNAGYDSA
480
DLVAQLRAAH
490
SEGRITAGLD
500
MKEGSIGDMA
510
VLGITESFQV
520
KRQVLLSAAE
530
AAEVILRVDN
540
IIKAAPRKRV
PDHHPC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005832 | chaperonin-containing T-complex |
| Cellular Component | GO:0002199 | zona pellucida receptor complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0140662 | ATP-dependent protein folding chaperone |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0007339 | binding of sperm to zona pellucida |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.