Overview
| Uniprot ID | A0A8I6GLN2 |
|---|
| Protein Name | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial |
|---|
| Gene Name | Acadsb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 278 |
PETSVLGKIGHGYKY |
Function
Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (butanoyl-CoA). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway. Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug
Protein Sequence
10
MAVSAFQLWR
20
AGGLLRRNFL
30
THSSSWKIPP
40
RVLKSSQPEA
50
LLSVTNNALC
60
FAPLQTFTDE
70
DIMMQKAVKK
80
FAQEQIAPLV
90
STMDENSKME
100
KSVIQGLFQQ
110
GMMGIEVEAK
120
YGGTEASFLC
130
SVLVIEELAK
140
VDASVALLCD
150
IQNTVINKLF
160
RKHGTEEQKA
170
TYLPKLVTEK
180
LGSFCLSEAG
190
AGSDSFALKT
200
RADKSGNYYV
210
INGSKMWISN
220
AEHAELFLVF
230
ANVDPPSGYR
240
GITCFLVDRD
250
TEGFQIGRRE
260
NKMGIRASST
270
CQLTFENVKV
280
PETSVLGKIG
290
HGYKYAIGSL
300
NEGRIGIAAQ
310
GLQHQVAHVA
320
TQLEAARLLT
330
YNAARLVEAG
340
RPFIKEASMA
350
KYYASEVAGL
360
TTSKCIEWMG
370
GVGYTKDYPV
380
EKFFRDAKIG
390
TIYEGTSNIQ
400
LNTIAKHIDA
EY
Gene Ontology
| Classification |
GO ID |
Description |
| Molecular Function |
GO:0050660 |
flavin adenine dinucleotide binding |
| Molecular Function |
GO:0003853 |
short-chain 2-methyl fatty acyl-CoA dehydrogenase activity |
| Biological Process |
GO:0006635 |
fatty acid beta-oxidation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.