Search Results

Overview

Uniprot ID	A0A8I6GM68
Protein Name	Protein deacetylase HDAC6
Gene Name	Hdac6
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
895	SASPVSAKGMTTPKG
903	GMTTPKGKVLEAGMR
911	VLEAGMRKPTAALPT
927	ESTLGQAKAKTAKAL
932	QAKAKTAKALLAQGQ

Function

Deacetylates a wide range of non-histone substrates (By similarity). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (By similarity). Required for cilia disassembly via deacetylation of alpha-tubulin (By similarity). Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (By similarity). Deacetylates SQSTM1. Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity (By similarity). Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (By similarity). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities (By similarity). Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage (By similarity). Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (PubMed:31068376). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis (By similarity). Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons (By similarity). Deacetylates PRDM16 (By similarity). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (By similarity). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy (By similarity)

Protein Sequence

10 MTSTGQDSST 20 RQRKSRHNPQ 30 SPLQDSSATL 40 KRGGKKGAVP 50 HSSPNLAEVK 60 KKGKMKKLSQ 70 PAEEDLIVGL 80 QGLDLNSETR 90 VPVGTGLVFD 100 EQLNDFHCLW 110 DDSFPENPER 120 LHAIKEQLIL 130 EGLLGRCVSF 140 QARFAEKEEL 150 MLVHSLEYID 160 LMETTQYMNE 170 GELRVLAGTY 180 DSVYLHPNSY 190 SCACLATGSV 200 LRLVDAVMGA 210 EIRNGMAVIR 220 PPGHHAQRSL 230 MDGYCMFNHL 240 AVAARYAQKK 250 HRIQRILIVD 260 WDVHHGQGTQ 270 FIFDQDPSVL 280 YFSIHRYEHG 290 RFWPHLKASN 300 WSTTGFGQGQ 310 GYTINVPWNQ 320 VSFCSHKLSL 330 ACFPRGSREM 340 TDYYIAFLCL 350 QVGMRDADYI 360 AAFLHILLPV 370 AFEFQPQLVL 380 VAAGFDALHG 390 DPKGEMSATP 400 AGFAHLTHFL 410 MGLAGGKLIL 420 SLEGGYNLHA 430 LAKGVSGSLH 440 TLLGDPCPML 450 ESPVAPCASA 460 QTSISCTLEA 470 LEPFWEVLER 480 SVEPQDEDEV 490 EGDMLEDEEE 500 EGHWEATALP 510 MDTWPLLQNR 520 TGLVYDERMM 530 SHCNLWDNHH 540 PETPQRILRI 550 MCHLEEVGLA 560 ARCLILPARP 570 ALDSELLTCH 580 SAEYVERLRA 590 TEKMKTRDLH 600 REGANFESIY 610 ICPSTFACAQ 620 LATGAACRLV 630 EAVLSGEVLN 640 GIAIVRPPGH 650 HAEPDAACGF 660 CFFNSVAVAA 670 RHAQVIAGRA 680 LRILIVDWDV 690 HHGNGTQHIF 700 EEDPSVLYVS 710 LHRYDRGTFF 720 PMGDEGASSQ 730 VGRAAGTGFT 740 VNVPWNGPRM 750 GDADYLATWH 760 RLVLPIAYEF 770 NPELVLISAG 780 FDAAQGDPLG 790 GCQVTPEGYA 800 HLTHLLMGLA 810 GGRIILILEG 820 GYNLTSISES 830 MAACTHSLLG 840 DPPPQLTSLR 850 PPQSGALASI 860 SEVIQVHRKY 870 WRSLRLMKME 880 DKEERSSSRL 890 VIKKLPQSAS 900 PVSAKGMTTP 910 KGKVLEAGMR 920 KPTAALPTKE 930 STLGQAKAKT 940 AKALLAQGQS 950 SEQAAKGTTL 960 DLATSKDTVG 970 GATTDQCASV 980 AATENSANQT 990 TSGEEASGET 1000 ESFGTSPSSN 1010 ASKQTTGASP 1020 LHGAAAQQSP 1030 ELGLSSTLEL 1040 SSEAQEVQES 1050 EEGLLGEAAG 1060 GQDMNSLMLT 1070 QGFGDFNTQD 1080 VFYAVTPLSW 1090 CPHLMAVCPI 1100 PAAGLDVSQP 1110 CKTCGSVQEN 1120 WVCLTCYQVY 1130 CSRYVNAHMV 1140 CHHEASEHPL 1150 VLSCVDLSTW 1160 CYLCQAYVHH 1170 EDLQDVKNAA 1180 HQNKFGEGMP HLQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016235	aggresome
Cellular Component	GO:0044297	cell body
Cellular Component	GO:0031252	cell leading edge
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0036064	ciliary basal body
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0000153	cytoplasmic ubiquitin ligase complex
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0000118	histone deacetylase complex
Cellular Component	GO:0016234	inclusion body
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005875	microtubule associated complex
Cellular Component	GO:0015630	microtubule cytoskeleton
Cellular Component	GO:0043005	neuron projection
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0043204	perikaryon
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0032991	protein-containing complex
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0043014	alpha-tubulin binding
Molecular Function	GO:0042030	ATPase inhibitor activity
Molecular Function	GO:0008013	beta-catenin binding
Molecular Function	GO:0048487	beta-tubulin binding
Molecular Function	GO:0019213	deacetylase activity
Molecular Function	GO:0070840	dynein complex binding
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0004407	histone deacetylase activity
Molecular Function	GO:0042826	histone deacetylase binding
Molecular Function	GO:0051879	Hsp90 protein binding
Molecular Function	GO:0008017	microtubule binding
Molecular Function	GO:0051787	misfolded protein binding
Molecular Function	GO:0036479	peroxidase inhibitor activity
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding
Molecular Function	GO:0033558	protein lysine deacetylase activity
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0048156	tau protein binding
Molecular Function	GO:0001222	transcription corepressor binding
Molecular Function	GO:0042903	tubulin deacetylase activity
Molecular Function	GO:0043130	ubiquitin binding
Molecular Function	GO:0061630	ubiquitin protein ligase activity
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0007015	actin filament organization
Biological Process	GO:0070842	aggresome assembly
Biological Process	GO:0019896	axonal transport of mitochondrion
Biological Process	GO:0070301	cellular response to hydrogen peroxide
Biological Process	GO:0071218	cellular response to misfolded protein
Biological Process	GO:0071374	cellular response to parathyroid hormone stimulus
Biological Process	GO:0035967	cellular response to topologically incorrect protein
Biological Process	GO:0061523	cilium disassembly
Biological Process	GO:0048668	collateral sprouting
Biological Process	GO:0060997	dendritic spine morphogenesis
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway
Biological Process	GO:0043131	erythrocyte enucleation
Biological Process	GO:0070846	Hsp90 deacetylation
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0032418	lysosome localization
Biological Process	GO:0051646	mitochondrion localization
Biological Process	GO:1905336	negative regulation of aggrephagy
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic
Biological Process	GO:0010727	negative regulation of hydrogen peroxide metabolic process
Biological Process	GO:0007026	negative regulation of microtubule depolymerization
Biological Process	GO:0010977	negative regulation of neuron projection development
Biological Process	GO:1901984	negative regulation of protein acetylation
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly
Biological Process	GO:0043242	negative regulation of protein-containing complex disassembly
Biological Process	GO:0045861	negative regulation of proteolysis
Biological Process	GO:0030182	neuron differentiation
Biological Process	GO:0070845	polyubiquitinated misfolded protein transport
Biological Process	GO:1900409	positive regulation of cellular response to oxidative stress
Biological Process	GO:1904056	positive regulation of cholangiocyte proliferation
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis
Biological Process	GO:0010634	positive regulation of epithelial cell migration
Biological Process	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
Biological Process	GO:0032461	positive regulation of protein oligomerization
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic
Biological Process	GO:0090044	positive regulation of tubulin deacetylation
Biological Process	GO:1905091	positive regulation of type 2 mitophagy
Biological Process	GO:0006476	protein deacetylation
Biological Process	GO:0035601	protein deacylation
Biological Process	GO:0031648	protein destabilization
Biological Process	GO:0000209	protein polyubiquitination
Biological Process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins
Biological Process	GO:0032984	protein-containing complex disassembly
Biological Process	GO:0070201	regulation of establishment of protein localization
Biological Process	GO:0045598	regulation of fat cell differentiation
Biological Process	GO:0016241	regulation of macroautophagy
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization
Biological Process	GO:0060632	regulation of microtubule-based movement
Biological Process	GO:0010821	regulation of mitochondrion organization
Biological Process	GO:0001932	regulation of protein phosphorylation
Biological Process	GO:0031647	regulation of protein stability
Biological Process	GO:0001975	response to amphetamine
Biological Process	GO:0051412	response to corticosterone
Biological Process	GO:0071548	response to dexamethasone
Biological Process	GO:0035902	response to immobilization stress
Biological Process	GO:0051788	response to misfolded protein
Biological Process	GO:0090042	tubulin deacetylation
Biological Process	GO:0061734	type 2 mitophagy
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process
Biological Process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Cellular Component	GO:0030424	axon
Cellular Component	GO:1904115	axon cytoplasm
Cellular Component	GO:0005901	caveola

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.