Overview
| Uniprot ID | A0A8I6GMH0 |
|---|
| Protein Name | Long-chain specific acyl-CoA dehydrogenase, mitochondrial |
|---|
| Gene Name | Acadl |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 298 |
RQRKAFGKTVAHIQT |
Function
Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase acts on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains. Probably responsible for beta-oxidation of bulky substrates including branched chain fatty acyl-CoAs and sterol derivatives thanks to its enlarged substrate-binding cavity
Protein Sequence
10
MIDLIFLIYV
20
SLRCSHSGAE
30
ARLETPSAKK
40
LTDIGIRRIF
50
SSEHDIFRES
60
VRKFFQEEVI
70
PYHEEWEKAG
80
EVSRELWEKA
90
GKQGLLGINI
100
AEKHGGIGGD
110
LLSTAVTWEE
120
QAYSNCTGPG
130
FSLHSDIVMP
140
YIANYGTKEQ
150
IEQFIPQMTA
160
GKCIGAIAMT
170
EPGLAHRASQ
180
CVWICLQVFI
190
TNGWLSDLVI
200
VVAVTNREAR
210
SPAHGISLFL
220
VENGMKGFIK
230
GKKLHKMGMK
240
AQDTAELFFE
250
DVRLPASALL
260
GEENKGFYYL
270
MQELPQERLL
280
IADLAISACE
290
FMFEETRNYV
300
RQRKAFGKTV
310
AHIQTVQHKL
320
AELKTNICVT
330
RAFVDSCLQL
340
HETKRLDSAS
350
ASMAKYWASE
360
LQNTVAYQCV
370
QLHGGWGYMW
380
EYPIAKAYVD
390
ARVQPIYGGT
400
NEIMKELIAR
QIVSDS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Molecular Function |
GO:0050660 |
flavin adenine dinucleotide binding |
| Molecular Function |
GO:0004466 |
long-chain fatty acyl-CoA dehydrogenase activity |
| Biological Process |
GO:0033539 |
fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| Biological Process |
GO:0042758 |
long-chain fatty acid catabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.