Search Results
Overview
| Uniprot ID | A0A8J8YFS5 |
|---|---|
| Protein Name | Histidine--tRNA ligase, cytoplasmic |
| Gene Name | Hars1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 42 | VTKLLKLKAQLGHDE |
Function
Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance
Protein Sequence
10
MADRAALEEL
20
VRLQGAHVRG
30
LKEQKASAEQ
40
IEEEVTKLLK
50
LKAQLGHDEG
60
KQKFVLKTPK
70
GTRDYSPRQM
80
AVREKVFDVI
90
IRCFKRHGAE
100
VIDTPVFELK
110
ETLTGKYGED
120
SKLIYDLKDQ
130
GGELLSLRYD
140
LTVPFARYLA
150
MNKLTNIKRY
160
HIAKVYRRDN
170
PAMTRGRYRE
180
FYQCDFDIAG
190
QFDPMIPDAE
200
CLKIMCEILS
210
SLQIGNFQVK
220
VNDRRILDGM
230
FAVCGVPDSK
240
FRTICSSVDK
250
LDKVSWEEVK
260
NEMVGEKGLA
270
PEVADRIGDY
280
VQQHGGVSLV
290
EQLLQDPKLS
300
QNKQAVEGLG
310
DLKLLFEYLT
320
LFGIDDKISF
330
DLSLARGLDY
340
YTGVIYEAVL
350
LQMPTQAGEE
360
PLGVGSIAAG
370
GRYDGLVGMF
380
DPKGRKVPCV
390
GLSIGVERIF
400
SIVEQKLEAS
410
EEKVRTTETQ
420
VLVASAQKKL
430
LEERLKLISE
440
LWDAGIKAEL
450
LYKKNPKLLN
460
QLQYCEEAGI
470
PLVAIIGEQE
480
LKDGVIKLRS
490
VTSREEVDVR
500
REDLVEEIRR
RTSQPLSM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004821 | histidine-tRNA ligase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006427 | histidyl-tRNA aminoacylation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.