Overview
| Uniprot ID | A0A8L2Q0A6 |
|---|
| Protein Name | ATP synthase peripheral stalk subunit F6, mitochondrial |
|---|
| Gene Name | Atp5pf |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 141 |
DRELFKLKQMYGKGE |
| 146 |
KLKQMYGKGEMDKFP |
Function
Subunit F6, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements
Protein Sequence
10
MRTVQCFQEG
20
KEGEVKCRKD
30
GGVLAEGPGS
40
TYPPLPPPVW
50
LLSHLEASGR
60
RLSSRRFLSD
70
STMTVQRIFR
80
LSSVLRSAVS
90
VHLRRNIGVT
100
AVAFNKELDP
110
VQKLFLDKIR
120
EYKAKRLASG
130
GPVDTGPEYQ
140
QEVDRELFKL
150
KQMYGKGEMD
160
KFPTFNFEDP
170
KFEVLDKPQS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0045259 |
proton-transporting ATP synthase complex |
| Molecular Function |
GO:0015078 |
proton transmembrane transporter activity |
| Biological Process |
GO:0015986 |
proton motive force-driven ATP synthesis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.