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Overview

Uniprot IDA0A8L2Q0J0
Protein NameSodium/potassium-transporting ATPase subunit beta
Gene NameAtp1b1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
113 IRFLEKYKDSAQKDD
13 AKEEGSWKKFIWNSE
14 KEEGSWKKFIWNSEK
21 KFIWNSEKKEFLGRT
215 LPVQCTGKRDEDKDK
276 TEIRIECKAYGENIG
287 ENIGYSEKDRFQGRF
7 *MARGKAKEEGSWKK

Function

Involved in cell adhesion and establishing epithelial cell polarity

Protein Sequence

10 MARGKAKEEG 20 SWKKFIWNSE 30 KKEFLGRTGG 40 SWFKILLFYV 50 IFYGCLAGIF 60 IGTIQVMLLT 70 ISELKPTYQD 80 RVAPPGLTQI 90 PQIQKTEISF 100 RPNDPKSYEA 110 YVLNIIRFLE 120 KYKDSAQKDD 130 MIFEDCGSMP 140 SEPKERGEFN 150 HERGERKVCR 160 FKLDWLGNCS 170 GLNDESYGYK 180 EGKPCIIIKL 190 NRVLGFKPPK 200 NESLETYPLT 210 MKYNPNVLPV 220 QCTGKRDEDK 230 DKVGNIEYFG 240 MGGFYGFPLQ 250 YYPYYGKLLQ 260 PKYLQPLLAV 270 QFTNLTLDTE 280 IRIECKAYGE 290 NIGYSEKDRF 300 QGRFDVKIEV KS

Gene Ontology

Classification GO ID Description
Biological Process GO:1903278 positive regulation of sodium ion export across plasma membrane
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0014704 intercalated disc
Cellular Component GO:0016328 lateral plasma membrane
Cellular Component GO:0031090 organelle membrane
Cellular Component GO:0005890 sodium:potassium-exchanging ATPase complex
Cellular Component GO:0036126 sperm flagellum
Cellular Component GO:0030315 T-tubule
Molecular Function GO:0001671 ATPase activator activity
Molecular Function GO:0051117 ATPase binding
Molecular Function GO:0005391 P-type sodium:potassium-exchanging transporter activity
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0141109 transporter activator activity
Biological Process GO:0046034 ATP metabolic process
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0030007 intracellular potassium ion homeostasis
Biological Process GO:0006883 intracellular sodium ion homeostasis
Biological Process GO:0086009 membrane repolarization
Biological Process GO:1903288 positive regulation of potassium ion import across plasma membrane
Biological Process GO:1990573 potassium ion import across plasma membrane
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0050821 protein stabilization
Biological Process GO:1903169 regulation of calcium ion transmembrane transport
Biological Process GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0055119 relaxation of cardiac muscle
Biological Process GO:0036376 sodium ion export across plasma membrane

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.