Overview
| Uniprot ID | A0A8L2Q0P3 |
|---|
| Protein Name | COP9 signalosome complex subunit 4 |
|---|
| Gene Name | Cops4 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 20 |
MNSSGSHKDLAGKYR |
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively
Protein Sequence
10
MAAAVRQDLA
20
QLMNSSGSHK
30
DLAGKYRQIL
40
EKAIQLSGTE
50
QLEALKAFVE
60
AMVNENVSLV
70
ISRQLLTDFC
80
THLPNLPDST
90
AKEVYHFTLE
100
KVQPRVISFE
110
EQVASIRQRL
120
ASIYEKEEDW
130
RNAAQVLVGI
140
PLETGQKQYN
150
DDDPVQAEAY
160
INRASLLQNE
170
STNEQLQIHY
180
KVCYARVLDY
190
RRKFIEAAQR
200
YNELSYKTIV
210
HESERLEALK
220
HALHCTILAS
230
AGQQRSRMLA
240
TLFKDERCQQ
250
LAAYGILEKM
260
YLDRIIRGNQ
270
PSRICCSSIL
280
DRAVIEHNLL
290
SASKLYNNIT
300
FEELGALLEI
310
PAAKAEKIAS
320
QMITEGRMNG
330
FIDQIDGIVH
340
FETREALPTW
350
DKQIQSLCFQ
360
VNNLLEKISQ
370
TAPEWTAQAM
EAQMAQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Biological Process |
GO:0000338 |
protein deneddylation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.