Search Results
Overview
| Uniprot ID | A0A8L2Q1G7 |
|---|---|
| Protein Name | Calreticulin |
| Gene Name | Calr |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 143 | ICGPGTKKVHVIFNY |
| 151 | VHVIFNYKGKNVLIN |
| 153 | VIFNYKGKNVLINKD |
| 159 | GKNVLINKDIRCKDD |
| 48 | KHKSDFGKFVLSSGK |
| 55 | KFVLSSGKFYGDQEK |
Function
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy
Protein Sequence
10
MLLSVPLLLG
20
LLGLAAADPA
30
IYFKEQFLDG
40
DAWTNRWVES
50
KHKSDFGKFV
60
LSSGKFYGDQ
70
EKDKGLQTSQ
80
DARFYALSAR
90
FEPFSNKGQT
100
LVVQFTVKHE
110
QNIDCGGGYV
120
KLFPGGLDQK
130
DMHGDSEYNI
140
MFGPDICGPG
150
TKKVHVIFNY
160
KGKNVLINKD
170
IRCKDDEFTH
180
LYTLIVRPDN
190
TYEPPKKIKD
200
PDAAKPEDWD
210
ERAKIDDPTD
220
SKPEDWDKPE
230
HIPDPDAKKP
240
EDWDEEMDGE
250
WEPPVIQNPE
260
YKGEWKPRQI
270
DNPDYKGTWI
280
HPEIDNPEYS
290
PDANIYAYDS
300
FAVLGLDLWQ
310
VKSGTIFDNF
320
LITNDEAYAE
330
EFGNETWGVT
340
KAAEKQMKDK
350
QDEEQRLKEE
360
EEDKKRKEEE
370
EAEDKEDEDD
380
RDEDEDEEDE
390
KEEDEEDATG
QAKDEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0060473 | cortical granule |
| Cellular Component | GO:0044194 | cytolytic granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0044322 | endoplasmic reticulum quality control compartment |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0042824 | MHC class I peptide loading complex |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005840 | ribosome |
| Cellular Component | GO:0033018 | sarcoplasmic reticulum lumen |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0030246 | carbohydrate binding |
| Molecular Function | GO:0001849 | complement component C1q complex binding |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0140313 | molecular sequestering activity |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0050681 | nuclear androgen receptor binding |
| Molecular Function | GO:0005049 | nuclear export signal receptor activity |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0090398 | cellular senescence |
| Biological Process | GO:0033144 | negative regulation of intracellular steroid hormone receptor signaling pathway |
| Biological Process | GO:0045665 | negative regulation of neuron differentiation |
| Biological Process | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0017148 | negative regulation of translation |
| Biological Process | GO:1901164 | negative regulation of trophoblast cell migration |
| Biological Process | GO:0002502 | peptide antigen assembly with MHC class I protein complex |
| Biological Process | GO:0045787 | positive regulation of cell cycle |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:2000510 | positive regulation of dendritic cell chemotaxis |
| Biological Process | GO:0010595 | positive regulation of endothelial cell migration |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
| Biological Process | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| Biological Process | GO:0006611 | protein export from nucleus |
| Biological Process | GO:0034504 | protein localization to nucleus |
| Biological Process | GO:0050821 | protein stabilization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.