Overview
| Uniprot ID | A0A8L2Q237 |
|---|
| Protein Name | ADP-ribosylation factor 6 |
|---|
| Gene Name | Arf6 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 69 |
WDVGGQDKIRPLWRH |
Function
GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes
Protein Sequence
10
MGKVLSKIFG
20
NKEMRILMLG
30
LDAAGKTTIL
40
YKLKLGQSVT
50
TIPTVGFNVE
60
TVTYKNVKFN
70
VWDVGGQDKI
80
RPLWRHYYTG
90
TQGLIFVVDC
100
ADRDRIDEAR
110
QELHRIINDR
120
EMRDAIILIF
130
ANKQDLPDAM
140
KPHEIQEKLG
150
LTRIRDRNCS
RIQGNLAR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0032154 |
cleavage furrow |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0060998 |
regulation of dendritic spine development |
| Biological Process |
GO:0010975 |
regulation of neuron projection development |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0031527 |
filopodium membrane |
| Cellular Component |
GO:0090543 |
Flemming body |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0055038 |
recycling endosome membrane |
| Molecular Function |
GO:0003925 |
G protein activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.