Search Results
Overview
| Uniprot ID | A0A8L2Q4B4 |
|---|---|
| Protein Name | Isocitrate dehydrogenase [NAD] subunit, mitochondrial |
| Gene Name | Idh3b |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 160 | HAVKEVFKAAAVPVE |
| 169 | AAVPVEFKEHHLSEV |
| 193 | EQVLSSMKENKVAII |
| 196 | LSSMKENKVAIIGKI |
| 240 | VKSLPGYKTRHNNLD |
| 275 | RGVIECLKIVTRTKS |
| 287 | TKSQRIAKFAFDYAT |
| 295 | FAFDYATKKGRSKVT |
| 300 | ATKKGRSKVTAVHKA |
| 306 | SKVTAVHKANIMKLG |
| 438 | SMIADAVKKVIKVGK |
| 462 | STTTDFIKSVIGHLH |
Function
Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers
Protein Sequence
10
MNRYTLTLVG
20
EKESPSLPGL
30
TGSLAPTTAL
40
ASGVTSPATP
50
SAEHGSAEQC
60
PLADPSEARD
70
ALGRGVGVRT
80
EGFSAVSKRG
90
QGHRGVRGLG
100
VPNLTLCLSQ
110
AVLGARNSGA
120
WRGLRTAASA
130
QAASQSQAQD
140
VRVEGAFPVT
150
MLPGDGVGPE
160
LMHAVKEVFK
170
AAAVPVEFKE
180
HHLSEVQNMA
190
SEEKLEQVLS
200
SMKENKVAII
210
GKIYTPMEYK
220
GELASYDMQL
230
RRKLDLFANV
240
VHVKSLPGYK
250
TRHNNLDLVI
260
IREQTEGEYS
270
SLEHESARGV
280
IECLKIVTRT
290
KSQRIAKFAF
300
DYATKKGRSK
310
VTAVHKANIM
320
KLGDGLFLQC
330
CEEVAELYPK
340
IKFETMIIDN
350
CCMQLVQNPY
360
QFDVLVMPNL
370
YGNIIDNLAA
380
GLVGGAGVVP
390
GESYSAEYAV
400
FETGARHPFA
410
QAVGRNIANP
420
TAMLLSASNM
430
LRHLNLEYHS
440
SMIADAVKKV
450
IKVGKVRTRD
460
MGGYSTTTDF
470
IKSVIGHLHP
HGG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0045242 | isocitrate dehydrogenase complex (NAD+) |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0051287 | NAD binding |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.