Search Results
Overview
| Uniprot ID | A0A8L2Q5B1 |
|---|---|
| Protein Name | Neuroplastin |
| Gene Name | Nptn |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 147 | ATISVLQKPRIVTSE |
| 243 | APDITGHKRSENKNE |
| 248 | GHKRSENKNEGQDAM |
Function
Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity. Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity. Promotes localization of XKR8 at the cell membrane
Protein Sequence
10
MSGSSLPGAL
20
ALSLLLVSGS
30
LLPGPGAAQN
40
AGFVKSPMSE
50
TKLTGDAFEL
60
YCDVVGSPTP
70
EIQWWYAEVN
80
RAESFRQLWD
90
GARKRRVTVN
100
TAYGSNGVSV
110
LRITRLTLED
120
SGTYECRASN
130
DPKRNDLRQN
140
PSITWIRAQA
150
TISVLQKPRI
160
VTSEEVIIRD
170
SLLPVTLQCN
180
LTSSSHTLMY
190
SYWTKNGVEL
200
TATRKNASNM
210
EYRINKPRAE
220
DSGEYHCVYH
230
FVSAPKANAT
240
IEVKAAPDIT
250
GHKRSENKNE
260
GQDAMMYCKS
270
VGYPHPEWMW
280
RKKENGVFEE
290
ISNSSGRFFI
300
INKENYTELN
310
IVNLQITEDP
320
GEYECNATNS
330
IGSASVSTVL
340
RVRSHLAPLW
350
PFLGILAEII
360
ILVVIIVVYE
370
KRKRPDEVPD
380
DDEPAGPMKT
390
NSTNNHKDKN
LRQRNTN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0001772 | immunological synapse |
| Cellular Component | GO:0014069 | postsynaptic density |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0001818 | negative regulation of cytokine production |
| Biological Process | GO:0007399 | nervous system development |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.