Search Results
Overview
| Uniprot ID | A0A8L2Q670 |
|---|---|
| Protein Name | NSFL1 cofactor p47 |
| Gene Name | Nsfl1c |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 127 | DDLFKGAKEHGAVAV |
| 220 | VKPKGAFKAFTGEGQ |
Function
Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis
Protein Sequence
10
MAEERQDALR
20
EFVAVTGAEE
30
DRARFFLESA
40
GWDLQIALAS
50
FYEDGGDEDI
60
VTISQATPSS
70
VSRGTAPSDN
80
RVTSFRDLIH
90
DQDEEEEEEE
100
GQRFYAGGSE
110
RSGQQIVGPP
120
RKKSPNELVD
130
DLFKGAKEHG
140
AVAVERVTKS
150
PGETSKPRVH
160
VVLKLWKTGF
170
SLDNGDLRSY
180
QDPSNAQFLE
190
SIRRGEVPAE
200
LRRLAHGGQV
210
NLDMEDHRDE
220
DFVKPKGAFK
230
AFTGEGQKLG
240
STAPQVLNTS
250
SPAQQAENEA
260
KASSSILINE
270
AEPTTNIQIR
280
LADGGRLVQK
290
FNHSHRISDI
300
RLFIVDARPA
310
MAATSFVLMT
320
TFPNKELADE
330
NQTLKEANLL
NAVIVQRLT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005795 | Golgi stack |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990730 | VCP-NSFL1C complex |
| Molecular Function | GO:0008289 | lipid binding |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.