Search Results
Overview
| Uniprot ID | A0A8L2Q6E3 |
|---|---|
| Protein Name | Hydroxymethylglutaryl-CoA lyase, mitochondrial |
| Gene Name | Hmgcl |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 136 | ASELFTRKNVNCSIE |
Function
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism
Protein Sequence
10
MATVRKAFPQ
20
RLVGLASLRA
30
ASTSSMGTLP
40
KRVKIVEVGP
50
RDGLQNEKSI
60
VPTPVKIKLI
70
DMLSEAGLPV
80
IEATSFVSPK
90
WVPQMADHSD
100
VLKGIQKFPG
110
INYPVLTPNM
120
KGFEEAVRGA
130
KEVSIFGAAS
140
ELFTRKNVNC
150
SIEESFQRFD
160
GVMQAARAAS
170
ISVRGYVSCA
180
LGCPYEGKVS
190
PAKVAEVAKK
200
LYSMGCYEIS
210
LGDTIGVGTP
220
GLMKDMLTAV
230
LHEVPVAALA
240
VHCHDTYGQA
250
LANTLVALQM
260
GVSVVDSSVA
270
GLGGCPYAKG
280
ASGNLATEDL
290
VYMLTGLGIH
300
TGVNLQKLLE
310
AGDFICQALN
320
RKTSSKVAQA
TCKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0004419 | hydroxymethylglutaryl-CoA lyase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006629 | lipid metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.