Search Results
Overview
| Uniprot ID | A0A8L2Q6N9 |
|---|---|
| Protein Name | Cytosolic acyl coenzyme A thioester hydrolase |
| Gene Name | Acot7 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 176 | LSLKNVDKVLEVPPI |
| 202 | RKRYEAQKLERMETK |
Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18. May play an important physiological function in brain
Protein Sequence
10
IPRMKLLART
20
LYLWEVGRQV
30
ASWSLTSGQE
40
CLVLRETWWA
50
SMRAVRTRAV
60
HHKPGHCIAM
70
GRIMRPDDAN
80
VAGNVHGGTI
90
LKMIEEAGVI
100
ISTRHCNSQN
110
GERCVAALAR
120
VERTDFLSPM
130
CIGEVAHVSA
140
EITYTSKHSV
150
EVQVHVLSEN
160
ILTGTKKLTN
170
KATLWYVPLS
180
LKNVDKVLEV
190
PPIVYLRQEQ
200
EEEGRKRYEA
210
QKLERMETKW
220
RNGDIVQPIL
230
NPEPNTVSYS
240
QSSLIHLVGP
250
SDCTLHGFVH
260
GGVTMKLMDE
270
VAGIVAARHC
280
KTNIVTASVD
290
AINFHDKIRK
300
GCVITISGRM
310
TFTSNKSMEI
320
EVLVDADPVV
330
DNSQKRYRAA
340
SAFFTYVSLN
350
QEGKPLPVPQ
360
LVPETEDEKK
370
RFEEGKGRYL
380
QMKAKRQGHT
EPQP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0052689 | carboxylic ester hydrolase activity |
| Molecular Function | GO:0036042 | long-chain fatty acyl-CoA binding |
| Molecular Function | GO:0052816 | long-chain fatty acyl-CoA hydrolase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0015937 | coenzyme A biosynthetic process |
| Biological Process | GO:0036116 | long-chain fatty-acyl-CoA catabolic process |
| Biological Process | GO:0051792 | medium-chain fatty acid biosynthetic process |
| Biological Process | GO:0036114 | medium-chain fatty-acyl-CoA catabolic process |
| Biological Process | GO:1900535 | palmitic acid biosynthetic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.