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Overview

Uniprot IDA0A8L2Q7P7
Protein NameRas-related protein Rab-3
Gene NameRab3c
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
179 AKDNINVKQTFERLV

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion

Protein Sequence

10 MELYGKMASA 20 QDARFGQKDS 30 SDQNFDYMFK 40 LLIIGNSSVG 50 KTSFLFRYAD 60 DSFTSAFVST 70 VGIDFKVKTV 80 FKNEKRIKLQ 90 IWDTAGQERY 100 RTITTAYYRG 110 AMGFILMYDI 120 TNEESFNAVQ 130 DWSTQIKTYS 140 WDNAQVILAG 150 NKCDMEDERV 160 VSTERGQRLG 170 EQLGFEFFET 180 SAKDNINVKQ 190 TFERLVDIIC 200 DKMSESLETD 210 PAITAAKQST 220 RLKETPPPPQ PNCGC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0003925 G protein activity
Molecular Function GO:0005525 GTP binding
Biological Process GO:0006886 intracellular protein transport

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.