Overview
| Uniprot ID | A0A8L2Q8H9 |
|---|
| Protein Name | Prohibitin |
|---|
| Gene Name | Phb2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 244 |
MLGEALSKNPGYIKL |
| 262 |
RAAQNISKTIATSQN |
Function
In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner. Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6
Protein Sequence
10
MAQNLKDLAG
20
RLPSGPRGMG
30
TALKLLLGAG
40
AVAYGVRESV
50
FTVEGGHRAI
60
FFNRIGGVQQ
70
DTILAEGLHF
80
RIPWFQYPII
90
YDIRARPRKI
100
SSPTGSKDLQ
110
MVNISLRVLS
120
RPNAQELPSM
130
YQRLGLDYEE
140
RVLPSIVNEV
150
LKSVVAKFNA
160
SQLITQRAQV
170
SLLIRRELTE
180
RAKDFSLILD
190
DVAITELSFS
200
REYTAAVEAK
210
QVAQQEAQRA
220
QFLVEKAKQE
230
QRQKIVQAEG
240
EAEAAKMLGE
250
ALSKNPGYIK
260
LRKIRAAQNI
270
SKTIATSQNR
280
IYLTADNLVL
290
NLQDESFTRA
D
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.