Search Results

Overview

Uniprot IDA0A8L2QAQ2
Protein NameTriosephosphate isomerase
Gene NameTpi1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
109 ARQKLDPKIAVAAQN
192 REAGITEKVVFEQTK
199 KVVFEQTKAIADNVK
206 KAIADNVKDWCKVVL
238 QAQEVHEKLRGWLKC
244 EKLRGWLKCNVSEGV
56 CAMAPSRKFFVGGNW

Function

It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids

Protein Sequence

10 TEGKAEQQGA 20 GLTMEEGGEK 30 EEFCFTAIYI 40 SGRWPEPSVC 50 SDLQRVDPCA 60 MAPSRKFFVG 70 GNWKMNGRKK 80 CLGELICTLN 90 AAKLPADTEV 100 VCAPPTAYID 110 FARQKLDPKI 120 AVAAQNCYKV 130 TNGAFTGEIS 140 PGMIKDLGAT 150 WVVLGHSERR 160 HIFGESDELI 170 GQKVNHALSE 180 GLGVIACIGE 190 KLDEREAGIT 200 EKVVFEQTKA 210 IADNVKDWCK 220 VVLAYEPVWA 230 IGTGKTATPQ 240 QAQEVHEKLR 250 GWLKCNVSEG 260 VAQCTRIIYG 270 GSVTGATCKE 280 LASQPDVDGF 290 LVGGASLKPE FVDIINAKQ

Gene Ontology

Classification GO ID Description
Molecular Function GO:0008929 methylglyoxal synthase activity
Molecular Function GO:0004807 triose-phosphate isomerase activity
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0006096 glycolytic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.