Search Results
Overview
| Uniprot ID | A0A8L2QC84 |
|---|---|
| Protein Name | Coactosin-like protein |
| Gene Name | Cotl1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 131 | TTGDAMSKRSKFALI |
| 177 | EFVISDRKELEEDFI |
| 66 | AMATKIDKEACRAAY |
Function
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis
Protein Sequence
10
MGVESRRALR
20
LCSNRGPLSE
30
DLSLQLRAAT
40
TPCSLSEPAR
50
PSQRIRDAFT
60
GSGSVLAAAM
70
ATKIDKEACR
80
AAYNLVRDDG
90
SSVIWVTFKY
100
DGATIVPGDQ
110
GADYQHFIQQ
120
CTDDVRLFAF
130
VRFTTGDAMS
140
KRSKFALITW
150
IGEDVSGLQR
160
AKTGTDKTLV
170
KEVVQNFAKE
180
FVISDRKELE
190
EDFIRSELKK
200
AGGANYDAQS
E
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0019899 | enzyme binding |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.