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Overview

Uniprot IDA0A8L2QDW8
Protein NamePyruvate carboxylase
Gene NamePc
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1091 QLRSILVKDTQAMKE
1110 PKALKDVKGQIGAPM
1125 PGKVIDVKVAAGAKV
435 VKVIAHGKDHPTAAT
749 KDMAGLLKPAACTML
993 LNLKELEKDLIDRHG

Function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second

Protein Sequence

10 MMLKFQTVRG 20 GLRLLGVRRS 30 STAPVASPNV 40 RRLEYKPIKK 50 VMVANRGEIA 60 IRVFRACTEL 70 GIRTVAVYSE 80 QDTGQMHRQK 90 ADEAYLIGRG 100 LAPVQAYLHI 110 PDIIKVAKEN 120 GVDAVHPGYG 130 FLSERADFAQ 140 ACQDAGVRFI 150 GPSPEVVRKM 160 GDKVEARAIA 170 IAAGVPVVPG 180 TNSPINSLHE 190 AHEFSNTYGF 200 PIIFKAAYGG 210 GGRGMRVVHS 220 YEELEENYTR 230 AYSEALAAFG 240 NGALFVEKFI 250 EKPRHIEVQI 260 LGDQYGNILH 270 LYERDCSIQR 280 RHQKVVEIAP 290 ATHLDPQLRS 300 RLTSDSVKLA 310 KQVGYENAGT 320 VEFLVDKHGK 330 HYFIEVNSRL 340 QVEHTVTEEI 350 TDVDLVHAQI 360 HVSEGRSLPD 370 LGLRQENIRI 380 NGCAIQCRVT 390 TEDPARSFQP 400 DTGRIEVFRS 410 GEGMGIRLDN 420 ASAFQGAVIS 430 PHYDSLLVKV 440 IAHGKDHPTA 450 ATKMSRALAE 460 FRVRGVKTNI 470 PFLQNVLNNQ 480 QFLAGIVDTQ 490 FIDENPELFQ 500 LRPAQNRAQK 510 LLHYLGHVMV 520 NGPTTPIPVK 530 VSPSPVDPIV 540 PVVPIGPPPA 550 GFRDILLREG 560 PEGFARAVRN 570 HQGLLLMDTT 580 FRDAHQSLLA 590 TRVRTHDLKK 600 IAPYVAHNFN 610 NLFSIENWGG 620 ATFDVAMRFL 630 YECPWRRLQE 640 LRELIPNIPF 650 QMLLRGANAV 660 GYTNYPDNVV 670 FKFCEVAKEN 680 GMDVFRIFDS 690 LNYLPNMLLG 700 MEAAGSAGGV 710 VEAAISYTGD 720 VADPSRTKYS 730 LEYYMGLAEE 740 LVRAGTHILC 750 IKDMAGLLKP 760 AACTMLVSSL 770 RDRFPDLPLH 780 IHTHDTSGSG 790 VAAMLACAQA 800 GADVVDVAVD 810 SMSGMTSQPS 820 MGALVACTKG 830 TPLDTEVPLE 840 RVFDYSEYWE 850 GARGLYAAFD 860 CTATMKSGNS 870 DVYENEIPGG 880 QYTNLHFQAH 890 SMGLGSKFKE 900 VKKAYVEANQ 910 MLGDLIKVTP 920 SSKIVGDLAQ 930 FMVQNGLSRA 940 EAEAQAEELS 950 FPRSVVEFLQ 960 GYIGIPHGGF 970 PEPFRSKVLK 980 DLPRIEGRPG 990 ASLPPLNLKE 1000 LEKDLIDRHG 1010 EEVTPEDVLS 1020 AAMYPDVFAQ 1030 FKDFTATFGP 1040 LDSLNTRLFL 1050 QGPKIAEEFE 1060 VELERGKTLH 1070 IKALAVSDLN 1080 RAGQRQVFFE 1090 LNGQLRSILV 1100 KDTQAMKEMH 1110 FHPKALKDVK 1120 GQIGAPMPGK 1130 VIDVKVAAGA 1140 KVVKGQPLCV 1150 LSAMKMETVV 1160 TSPMEGTIRK 1170 VHVTKDMTLE GDDLILEIE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0009374 biotin binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004736 pyruvate carboxylase activity
Biological Process GO:0019752 carboxylic acid metabolic process
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0006629 lipid metabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.