Overview
| Uniprot ID | A0A8L2QFA3 |
|---|
| Protein Name | Src substrate cortactin |
|---|
| Gene Name | Cttn |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 107 |
VGHEYQSKLSKHCSQ |
| 110 |
EYQSKLSKHCSQVDS |
| 124 |
SVRGFGGKFGVQMDR |
| 144 |
VGFEYQGKTEKHASQ |
| 152 |
TEKHASQKDYSSGFG |
| 161 |
YSSGFGGKYGVQADR |
| 171 |
VQADRVDKSAVGFDY |
| 181 |
VGFDYQGKTEKHESQ |
| 193 |
ESQKDYSKGFGGKYG |
| 198 |
YSKGFGGKYGIDKDK |
| 205 |
KYGIDKDKVDKSAVG |
| 208 |
IDKDKVDKSAVGFEY |
| 218 |
VGFEYQGKTEKHESQ |
| 235 |
YVKGFGGKFGVQTDR |
| 267 |
ESQKDYAKGFGGKYG |
| 272 |
YAKGFGGKYGVQKDR |
| 277 |
GGKYGVQKDRMDKVR |
| 309 |
ANFENLAKEREQEDR |
| 42 |
KEQRWGAKTVQGSGH |
| 57 |
QEHINIHKLRENVFQ |
| 70 |
FQEHQTLKEKELETG |
| 79 |
KELETGPKASHGYGG |
| 87 |
ASHGYGGKFGVEQDR |
| 97 |
VEQDRMDKSAVGHEY |
Function
Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density. Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane. Plays a role in receptor-mediated endocytosis via clathrin-coated pits. Required for stabilization of KCNH1 channels at the cell membrane
Protein Sequence
10
MWKASAGHAV
20
SITQDDGGAD
30
DWETDPDFVN
40
DVSEKEQRWG
50
AKTVQGSGHQ
60
EHINIHKLRE
70
NVFQEHQTLK
80
EKELETGPKA
90
SHGYGGKFGV
100
EQDRMDKSAV
110
GHEYQSKLSK
120
HCSQVDSVRG
130
FGGKFGVQMD
140
RVDQSAVGFE
150
YQGKTEKHAS
160
QKDYSSGFGG
170
KYGVQADRVD
180
KSAVGFDYQG
190
KTEKHESQKD
200
YSKGFGGKYG
210
IDKDKVDKSA
220
VGFEYQGKTE
230
KHESQKDYVK
240
GFGGKFGVQT
250
DRQDKCALGW
260
DHQEKLQLHE
270
SQKDYAKGFG
280
GKYGVQKDRM
290
DKVRLMCPLF
300
PLVTSKTSNI
310
RANFENLAKE
320
REQEDRRKAE
330
AERAQRMAQE
340
RQEQEEARRK
350
LEEQARAKKQ
360
TPPASPSPQP
370
AEDRPPSSPI
380
YEDAAPLKAE
390
PSYGSSEPEP
400
EYSTEAAGLP
410
EASNQQGLAY
420
TSEPVYETTE
430
VPGHYQAEDD
440
TYDGYESDLG
450
ITAIALYDYQ
460
AAGDDEISFD
470
PDDVITNIEM
480
IDDGWWRGVC
490
KGRYGLFPAN
YVELRQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005938 |
cell cortex |
| Cellular Component |
GO:0005905 |
clathrin-coated pit |
| Cellular Component |
GO:0043197 |
dendritic spine |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0002102 |
podosome |
| Cellular Component |
GO:0001726 |
ruffle |
| Biological Process |
GO:0006897 |
endocytosis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.