Search Results
Overview
| Uniprot ID | A0A8L2QG09 |
|---|---|
| Protein Name | Inosine triphosphate pyrophosphatase |
| Gene Name | Itpa |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 174 | AEMPKAEKNTISHRF |
Function
Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions
Protein Sequence
10
MAASLVGKKI
20
VFVTGNAKKL
30
EEVIQILGDK
40
FPCTLVAQKI
50
DLPEYQGEPD
60
EISIQKCQEA
70
ARQVQGPVLV
80
EDTCLCFNAL
90
GGLPGPYIQC
100
GFTEPHYVPA
110
GLYQLLAGFE
120
DKSAYALCTF
130
ALSTGDPSQP
140
VLLFRGKTPG
150
QIVMPRGSRD
160
FGWDPCFQPD
170
GYEQTYAEMP
180
KAEKNTISHR
190
FRALFKLQEY
200
FGVTDGAGDH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0035870 | dITP diphosphatase activity |
| Molecular Function | GO:0036220 | ITP diphosphatase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Molecular Function | GO:0036222 | XTP diphosphatase activity |
| Biological Process | GO:0009204 | deoxyribonucleoside triphosphate catabolic process |
| Biological Process | GO:0009117 | nucleotide metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.