Overview
| Uniprot ID | A0A8L2QG86 |
|---|
| Protein Name | ATP synthase F(0) complex subunit f, mitochondrial |
|---|
| Gene Name | Atp5mf |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 29 |
EKKLMEVKLRELPSW |
| 61 |
GYDRYYNKYINVRKG |
Function
Subunit f, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain
Protein Sequence
10
MCYICAQSGS
20
RGASVYFMPL
30
KEKKLMEVKL
40
RELPSWILMR
50
DFTPSGIAGA
60
FRRGYDRYYN
70
KYINVRKGSI
80
SGINMVLAAY
90
VVFSYCISYK
100
ELKHERRRKY
H
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0045259 |
proton-transporting ATP synthase complex |
| Biological Process |
GO:0006754 |
ATP biosynthetic process |
| Biological Process |
GO:1902600 |
proton transmembrane transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.