Search Results
Overview
| Uniprot ID | A0A8L2QQT4 |
|---|---|
| Protein Name | Serine/threonine-protein kinase DCLK2 |
| Gene Name | Dclk2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 183 | TLAVASAKSEVKESK |
| 301 | YSRASAAKYSGSRSP |
Function
Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm
Protein Sequence
10
MASTRSIELE
20
HFEERDKRPR
30
PGSRRGAPSS
40
SGGSSISGPK
50
GNGLIPSPAH
60
SAHCSFYRTR
70
TLQALSSEKK
80
AKKARFYRNG
90
DRYFKGLVFA
100
ISSDRFRSFD
110
ALLIELTRSL
120
SDNVNLPQGV
130
RTIYTVDGSR
140
KVTSLDELLE
150
GESYVCASNE
160
PFRKVDYTKN
170
VNPNWSVNIK
180
GGTTRTLAVA
190
SAKSEVKESK
200
DFIKPKLVTV
210
IRSGVKPRKA
220
VRILLNKKTA
230
HSFEQVLTDI
240
TEAIKLDSGV
250
VKRLCTLDGK
260
QVTCLQDFFG
270
DDDVFIACGP
280
EKYRYAQDDF
290
VLDHSECRVL
300
KSSYSRASAA
310
KYSGSRSPGL
320
SRRSKSPASV
330
NGTPSSQLST
340
PKSTKSSSSS
350
PTSPGSFRGL
360
KISAQGRSSS
370
NVNGGPELDR
380
CMSPEGVNGN
390
RCSESFTLLE
400
KYRIGKVIGD
410
GNFAVVKECM
420
DRSTGKEFAL
430
KIIDKAKCCG
440
KEHLIENEVS
450
ILRRVKHPNI
460
IMLVEEMETT
470
TELFLVMELV
480
KGGDLFDAIT
490
SSTKYTERDG
500
SAMVYNLASA
510
LRYLHGLSIV
520
HRDIKPENLL
530
VCEYPDGTKS
540
LKLGDFGLAT
550
VVEGPLYTVC
560
GTPTYVAPEI
570
IAETGYGLKV
580
DVWAAGVITY
590
ILLCGFPPFR
600
SENNLQEDLF
610
DQILAGKLEF
620
PAPYWDNITD
630
SAKELISQML
640
QVNVEARCTA
650
GEILSHPWVS
660
DDASQENNMQ
670
AEVTGKLKQH
680
FNNALPKQNS
690
TTTGVSVIMV
QGHEHGSR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Biological Process | GO:0035556 | intracellular signal transduction |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.