Overview
| Uniprot ID | A0A8L2QV96 |
|---|
| Protein Name | Protein IMPACT |
|---|
| Gene Name | Impact |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 281 |
NSPEESAKSFGKKKV |
| 96 |
IRDALIQKSQITEPG |
Function
Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth
Protein Sequence
10
NAQAECGQNE
20
EIEAMAAIYG
30
EEWCVIDEVA
40
KIFCIRITDD
50
MDDPKWTLCL
60
QVIFSYTFWQ
70
ERAELAKSLE
80
EIYMKNIGES
90
ILYQWVEKIR
100
DALIQKSQIT
110
EPGPDEKKKT
120
EEEEVEGEDD
130
PILEHPPENP
140
VKTWDLKISE
150
SAPEAEELPP
160
IAHGAPITDR
170
RSTFQAHLAP
180
VVCIDQVKKV
190
LAKLYENKKI
200
ASATHNIYAY
210
RIYCEDKQTF
220
LQDSEDDGET
230
AAGGRLLHLM
240
EILNVKNVMV
250
VVSRWYGGIL
260
LGPDRFKHIN
270
NCARNILVEK
280
NFTNSPEESA
290
KSFGKKKVKK
DKKKGDH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Biological Process |
GO:0006417 |
regulation of translation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.