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Overview

Uniprot IDA0A8L2QVM1
Protein NameSerine/threonine-protein kinase DCLK2
Gene NameDclk2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
183 TLAVASAKSEVKESK
301 YSRASAAKYSGSRSP

Function

Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm

Protein Sequence

10 MASTRSIELE 20 HFEERDKRPR 30 PGSRRGAPSS 40 SGGSSISGPK 50 GNGLIPSPAH 60 SAHCSFYRTR 70 TLQALSSEKK 80 AKKARFYRNG 90 DRYFKGLVFA 100 ISSDRFRSFD 110 ALLIELTRSL 120 SDNVNLPQGV 130 RTIYTVDGSR 140 KVTSLDELLE 150 GESYVCASNE 160 PFRKVDYTKN 170 VNPNWSVNIK 180 GGTTRTLAVA 190 SAKSEVKESK 200 DFIKPKLVTV 210 IRSGVKPRKA 220 VRILLNKKTA 230 HSFEQVLTDI 240 TEAIKLDSGV 250 VKRLCTLDGK 260 QVTCLQDFFG 270 DDDVFIACGP 280 EKYRYAQDDF 290 VLDHSECRVL 300 KSSYSRASAA 310 KYSGSRSPGL 320 SRRSKSPASV 330 KRAGHSSAYS 340 TAKSPVNGTP 350 SSQLSTPKST 360 KSSSSSPTSP 370 GSFRGLKQIS 380 AQGRSSSNVN 390 GGPELDRCMS 400 PEGVNGNRCS 410 ESFTLLEKYR 420 IGKVIGDGNF 430 AVVKECMDRS 440 TGKEFALKII 450 DKAKCCGKEH 460 LIENEVSILR 470 RVKHPNIIML 480 VEEMETTTEL 490 FLVMELVKGG 500 DLFDAITSST 510 KYTERDGSAM 520 VYNLASALRY 530 LHGLSIVHRD 540 IKPENLLVCE 550 YPDGTKSLKL 560 GDFGLATVVE 570 GPLYTVCGTP 580 TYVAPEIIAE 590 TGYGLKVDVW 600 AAGVITYILL 610 CGFPPFRSEN 620 NLQEDLFDQI 630 LAGKLEFPAP 640 YWDNITDSAK 650 ELISQMLQVN 660 VEARCTAGEI 670 LSHPWVSDDA 680 SQENNMQAEV 690 TGKLKQHFNN 700 ALPKQNSTTT 710 GVSVIMVSPR P

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005856 cytoskeleton
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0004674 protein serine/threonine kinase activity
Biological Process GO:0021954 central nervous system neuron development
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:1900181 negative regulation of protein localization to nucleus
Biological Process GO:0034504 protein localization to nucleus

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.