Overview
| Uniprot ID | A0A8L2QWG8 |
|---|
| Protein Name | ATP synthase subunit b |
|---|
| Gene Name | Atp5pb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 126 |
IDKLNEEKIAQLEEI |
| 134 |
IAQLEEIKQSSMKQI |
| 139 |
EIKQSSMKQIQDAIN |
| 149 |
QDAINREKAQQALVQ |
| 157 |
AQQALVQKRHYLFDV |
| 205 |
VQDMMRRKEGEHMIN |
| 228 |
SISAQQEKETIAKCI |
| 233 |
QEKETIAKCIGDLKM |
Function
Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements
Protein Sequence
10
LLSQVSLHLI
20
GIAFCIMVAC
30
RVLQATRVFH
40
TGQPRLAPLP
50
PLPEYGGKVR
60
LGLIPEEFFQ
70
FLYPKTGVTG
80
PYVLGTGLSL
90
YFLSKEIYVI
100
TPETFSTISV
110
VGLIVYVIKK
120
YGASIGEFID
130
KLNEEKIAQL
140
EEIKQSSMKQ
150
IQDAINREKA
160
QQALVQKRHY
170
LFDVQRNNIA
180
LALEVTYRER
190
LHKAYKEVKN
200
RLDYHISVQD
210
MMRRKEGEHM
220
INWVEKHVIQ
230
SISAQQEKET
240
IAKCIGDLKM
250
LAKKAQAQPI
M
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0045259 |
proton-transporting ATP synthase complex |
| Molecular Function |
GO:0015078 |
proton transmembrane transporter activity |
| Biological Process |
GO:0015986 |
proton motive force-driven ATP synthesis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.