Search Results
Overview
| Uniprot ID | A0A8L2QX68 |
|---|---|
| Protein Name | Wiskott-Aldrich syndrome protein family member |
| Gene Name | Wasf1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 189 | DRPHEPEKVPRAPHD |
| 203 | DRRREWQKLAQGPEL |
Function
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. Also involved in the regulation of mitochondrial dynamics
Protein Sequence
10
MPLVKRNIDP
20
RHLCHTALPR
30
GIKNELECVT
40
NISLANIIRQ
50
LSKYAEDIFG
60
ELFNEAHSFS
70
FRVNSLQERV
80
DRLSVSVTQL
90
DPKEEELSLQ
100
DITMRKAFRS
110
STIQDQQLFD
120
RKTLPIPLQE
130
TYDVCEQPPP
140
LNVLTPYRDD
150
GKEGLKFYTN
160
PSYFFDLWKE
170
KMLQDTEDKR
180
KEKRKQKQKN
190
LDRPHEPEKV
200
PRAPHDRRRE
210
WQKLAQGPEL
220
AEDDADLLHK
230
HIEVANGPAS
240
HFETRPQTYV
250
DHMDGSYSLS
260
ALPFSQMSEL
270
LSRAEERVLV
280
RPHEPPPPPP
290
MHAAGDARPT
300
PTCVSSAAGL
310
IENRPQSPAA
320
GRTPVFVSPT
330
PPPPPPPLPS
340
ALSTSSLRAS
350
MTSTPPPPVP
360
PPPPPPAPAL
370
QAPAVPPPPA
380
PLQIAPGVLH
390
PAPPPIAPPL
400
VQPSPPVARA
410
APVCETVPVH
420
PLPQGEVQGL
430
PPPPPPPPLP
440
PPGIRPSSPV
450
TVAALAHPPS
460
GLHPTPSPAP
470
GPHAPLMPPS
480
PPSQVLPASE
490
PKRHPSTLPV
500
ISDARSVLLE
510
AIRKGIQLRK
520
VEEQREQEAK
530
HERIENDVAT
540
ILSRRIAVEY
550
SDSEDDSEFD
EVDWLE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0031209 | SCAR complex |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051018 | protein kinase A binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus |
| Biological Process | GO:0097484 | dendrite extension |
| Biological Process | GO:0072673 | lamellipodium morphogenesis |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:0098885 | modification of postsynaptic actin cytoskeleton |
| Biological Process | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation |
| Biological Process | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway |
| Biological Process | GO:0016601 | Rac protein signal transduction |
| Biological Process | GO:0006898 | receptor-mediated endocytosis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.