Search Results
Overview
| Uniprot ID | A0A8L2QXM0 |
|---|---|
| Protein Name | Astrocytic phosphoprotein PEA-15 |
| Gene Name | Pea15 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 132 | DYRTRVLKISEEDEL |
| 142 | EEDELDTKLTRIPSA |
| 172 | IKLAPPPKKA***** |
| 72 | EQLKSACKEDIPSEK |
Function
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface
Protein Sequence
10
LHGRKRRRRQ
20
DRRQRWPEPR
30
SRLQTLLRNR
40
GSGSARTLSS
50
QLRRRAEYGT
60
LLQDLTNNIT
70
LEDLEQLKSA
80
CKEDIPSEKS
90
EEITTGSAWF
100
SFLESHNKLD
110
KDNLSYIEHI
120
FEISRRPDLL
130
TMVVDYRTRV
140
LKISEEDELD
150
TKLTRIPSAK
160
KYKDIIRQPS
170
EEEIIKLAPP
PKKA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0000165 | MAPK cascade |
| Biological Process | GO:0046325 | negative regulation of D-glucose import across plasma membrane |
| Biological Process | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.