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Overview

Uniprot ID	A0A8L2QXS1
Protein Name	Rho GTPase-activating protein 44
Gene Name	Arhgap44
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
175	SLQPAGAKADALREE

Function

GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation. In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation

Protein Sequence

10 MKKQFNRMRQ 20 LANQTVGRAE 30 KTEVLSEDLL 40 QVEKRLELVK 50 QVSHSTHKKL 60 TACLQGQQGA 70 EADKRSKKLP 80 LTTLAQCLME 90 GSAILGDDTL 100 LGKMLKLCGE 110 TEDELAQELI 120 HFELRVERDV 130 IEPLFLLAEV 140 EIPNIQKQRK 150 HLAKLVLDMD 160 SSRTRWQQTS 170 KSSGLSSSLQ 180 PAGAKADALR 190 EEMEEAANRV 200 EICRDQLSAD 210 MYSFVAKEID 220 YANYFQTLIE 230 VQAEYHRKSL 240 TLLQAVLPQI 250 KAQQEAWVEK 260 PSFGKPLEEH 270 LMISGREIAF 280 PIEACVTMLL 290 ECGMQEEGLF 300 RVAPSASKLK 310 KLKAALDCCV 320 VDVQEYSADP 330 HAIAGALKSY 340 LRELPEPLMT 350 FELYDEWIQA 360 SNIQEQDKRL 370 QALWNACEKL 380 PKANHNNIRY 390 LIKFLSKLSE 400 YQDVNKMTPS 410 NMAIVLGPNL 420 LWPQSEGNIT 430 EMMTTVSLQI 440 VGIIEPIIQH 450 ADWFFPGEIE 460 FNITGSYGSP 470 VHVNHNANYS 480 SMPSPDMDPA 490 DRRQPEQARR 500 PLSVATDNMM 510 LEFYKKDGLR 520 KIQSVSKSKE 530 LSPGSGQKGS 540 PGSIQGTTCP 550 GTQLGPQPAA 560 SPSQLPADQS 570 PHTLRKVSKK 580 LAPIPPKVPF 590 VQPGTVSDQP 600 TGQPSPVSLS 610 PTPPSTPSPY 620 GLSYPPGYSM 630 ASGQLSPASA 640 PPLASPSVFT 650 STLAKSRPTP 660 KPRQRPTLPP 670 PQPPSVSLSA 680 SSPQSTEHPM 690 LDGMSPGESM 700 STDLVHFDVP 710 SIHIELGSTL 720 RLSPLEHARR 730 HSVTDKRDSE EESESTAL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0005096	GTPase activator activity
Biological Process	GO:0007165	signal transduction

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.