Overview
| Uniprot ID | A0A8L2R003 |
|---|
| Protein Name | Platelet-activating factor acetylhydrolase IB subunit alpha2 |
|---|
| Gene Name | Pafah1b2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 140 |
PLRQKNAKVNQLLKV |
| 146 |
AKVNQLLKVSLPKLA |
Function
Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE. May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis
Protein Sequence
10
MQQKIFKEMT
20
GGCLRFVLDC
30
KDKEPDVLFV
40
GDSMVQLMQQ
50
YEIWRELFSP
60
LHALNFGIGG
70
DTTRHVLWRL
80
KNGELENIKP
90
KVIVVWVGTN
100
NHENTAEEVA
110
GGIEAIVQLI
120
NTRQPQAKII
130
VLGLLPRGEK
140
PNPLRQKNAK
150
VNQLLKVSLP
160
KLANVQLLDI
170
DGGFVHSDGA
180
ISCHDMFDFL
190
HLTGGGYAKI
200
CKPLHELIMQ
210
LLEETPEEKQ
TTIA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008247 |
1-alkyl-2-acetylglycerophosphocholine esterase complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0003847 |
1-alkyl-2-acetylglycerophosphocholine esterase activity |
| Molecular Function |
GO:0047179 |
platelet-activating factor acetyltransferase activity |
| Biological Process |
GO:0016042 |
lipid catabolic process |
| Biological Process |
GO:0016239 |
positive regulation of macroautophagy |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.