Search Results
Overview
| Uniprot ID | A0A8L2R3X1 |
|---|---|
| Protein Name | Ribose-phosphate pyrophosphokinase 1 |
| Gene Name | Prps1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 176 | SPDAGGAKRYVTSIA |
Function
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis
Protein Sequence
10
MPNIKIFSGS
20
SHQDLSQKIA
30
DRLGLELGKV
40
VTKKFSNQET
50
CVEIGESVRG
60
EDVYIVQSGC
70
GEINDNLMEL
80
LIMINACKIA
90
SASRVTAVIP
100
CFPYARQDKK
110
DKSRAPISAK
120
LVANMLSVAG
130
ADHIITMDLH
140
ASQIQGFFDI
150
PVDNLYAEPA
160
VLKWIRENIS
170
EWRNCTIVSP
180
DAGGAKRYVT
190
SIADRLNVDF
200
ALIHKERKKA
210
NEVDRMVLVG
220
DVKDRVAILV
230
DDMADTCGTI
240
CHAADKLLSA
250
GATRVYAILT
260
HGIFSGPAIS
270
RINNACFEAV
280
VVTNTIPQED
290
KMKHCSKIQV
300
IDISMILAEA
310
IRRTHNGESV
SYLFSHVPL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0043531 | ADP binding |
| Molecular Function | GO:0016208 | AMP binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0019003 | GDP binding |
| Molecular Function | GO:0016301 | kinase activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004749 | ribose phosphate diphosphokinase activity |
| Biological Process | GO:0006015 | 5-phosphoribose 1-diphosphate biosynthetic process |
| Biological Process | GO:0006167 | AMP biosynthetic process |
| Biological Process | GO:0031100 | animal organ regeneration |
| Biological Process | GO:0008584 | male gonad development |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.