Search Results
Overview
| Uniprot ID | A0A8L2R3X6 |
|---|---|
| Protein Name | Palmitoyl-protein thioesterase ABHD10, mitochondrial |
| Gene Name | Abhd10 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | LSNMNGKKAVAIEEF |
Function
Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate
Protein Sequence
10
MRLLGRNKSH
20
VMQVSNLRLP
30
ADCACVTSGP
40
RDRCTSVAGA
50
GVAGKMAAWV
60
PCRKWGWAAV
70
SFGRHRGLIA
80
SLARKPPWAW
90
WLSACRQKTT
100
LSFLKRPELP
110
SLAYKRLKGK
120
NPGIIFIPGY
130
LSNMNGKKAV
140
AIEEFCKSIG
150
HAFIRFDYSG
160
VGSSDGNLAE
170
CSVGKWRKDV
180
LSILDDIAEG
190
PQILVGSSLG
200
GWLMLHAAIA
210
RPEKVIALIG
220
IASATDGVVT
230
QFHSLPVEMQ
240
KEIEMKGEWS
250
LPSKYNKEGY
260
YSIPYSFIKE
270
AAHHCLLHSP
280
IPVTCPVRLL
290
HGMKDEIVPW
300
HRSLQVADRV
310
VSPDVDVILR
320
KHSDHRMKET
330
ADIHLLICTI
340
DDLIDKLSTV
TH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
| Molecular Function | GO:0102390 | mycophenolic acid acyl-glucuronide esterase activity |
| Molecular Function | GO:0008474 | palmitoyl-(protein) hydrolase activity |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.