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Overview

Uniprot IDA0A8L2R622
Protein NameCoatomer subunit delta
Gene NameArcn1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
233 LKLGAKGKEVDNFVD

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins

Protein Sequence

10 MVLLAAAVCT 20 KAGKAIVSRQ 30 FVEMTRTRIE 40 GLLAAFPKLM 50 NTGKQHTFVE 60 TESVRYVYQP 70 MEKLYMVLIT 80 TKNSNILEDL 90 ETLRLFSRVI 100 PEYCRALEEN 110 EISEHCFDLI 120 FAFDEIVALG 130 YRENVNLAQI 140 RTFTEMDSHE 150 EKVFRAVRET 160 QEREAKAEMR 170 RKAKELQQAR 180 RDAERQGKKA 190 PGFGGFGSSA 200 VSGGSTAAMI 210 TETIIETDKP 220 KVAPAPARPS 230 GPSKALKLGA 240 KGKEVDNFVD 250 KLKSEGETIM 260 SSNMGKRTSE 270 AAKVHAPPIN 280 MESVHMKIEE 290 KITLTCGRDG 300 GLQNMELHGM 310 IMLRISDDKF 320 GRIRLHVENE 330 DKKGTHPNVD 340 KKLFTAESLI 350 GLKNPEKSFP 360 VNSDVGVLKW 370 RLQTTEESFI 380 PLTINCWPSE 390 SGNGCDVNIE 400 YELQEDNLEL 410 NDVVITIPLP 420 SGVGAPVIGE 430 IDGEYRHDSR 440 RNTLEWCLPV 450 IDAKNKSGSL 460 EFSIPGQPND 470 FFPVQVSFIS 480 KKNYCNIQVT 490 KVTQVDGNSP 500 VRFSTETTFL VDKYEIL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030126 COPI vesicle coat
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0000139 Golgi membrane
Biological Process GO:0015031 protein transport
Biological Process GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.