Overview
| Uniprot ID | A0A8L2R6N8 |
|---|
| Protein Name | Aquaporin-4 |
|---|
| Gene Name | Aqp4 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 309 |
RLKEAFSKAAQQTKG |
| 315 |
SKAAQQTKGSYMEVE |
| 352 |
IDRGDEKKGKDSSGE |
| 354 |
RGDEKKGKDSSGEVL |
Function
Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability
Protein Sequence
10
MVQNLSTPTL
20
QKPNQTSARN
30
LIPEHWSLGA
40
GNESCTPARE
50
GMSDGAAARR
60
WGKCGPPCSR
70
ESIMVAFKGV
80
WTQAFWKAVT
90
AEFLAMLIFV
100
LLSVGSTINW
110
GGSENPLPVD
120
MVLISLCFGL
130
SIATMVQCFG
140
HISGGHINPA
150
VTVAMVCTRK
160
ISIAKSVFYI
170
TAQCLGAIIG
180
AGILYLVTPP
190
SVVGGLGVTT
200
VHGNLTAGHG
210
LLVELIITFQ
220
LVFTIFASCD
230
SKRTDVTGSV
240
ALAIGFSVAI
250
GHLFAINYTG
260
ASMNPARSFG
270
PAVIMGNWEN
280
HWIYWVGPII
290
GAVLAGALYE
300
YVFCPDVELK
310
RRLKEAFSKA
320
AQQTKGSYME
330
VEDNRSQVET
340
EDLILKPGVV
350
HVIDIDRGDE
360
KKGKDSSGEV
LSSV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0097450 |
astrocyte end-foot |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0042383 |
sarcolemma |
| Molecular Function |
GO:0015250 |
water channel activity |
| Biological Process |
GO:0009992 |
intracellular water homeostasis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.