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Overview

Uniprot IDA0A8L2R781
Protein NameRas-related protein Rab-3
Gene NameRab3c
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
175 AKDNINVKQTFERLV

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion

Protein Sequence

10 MRMASAQDAR 20 FGQKDSSDQN 30 FDYMFKLLII 40 GNSSVGKTSF 50 LFRYADDSFT 60 SAFVSTVGID 70 FKVKTVFKNE 80 KRIKLQIWDT 90 AGQERYRTIT 100 TAYYRGAMGF 110 ILMYDITNEE 120 SFNAVQDWST 130 QIKTYSWDNA 140 QVILAGNKCD 150 MEDERVVSTE 160 RGQRLGEQLG 170 FEFFETSAKD 180 NINVKQTFER 190 LVDIICDKMS 200 ESLETDPAIT 210 AAKQSTRLKE 220 TPPPPQPNCG C

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0003925 G protein activity
Molecular Function GO:0005525 GTP binding
Biological Process GO:0006886 intracellular protein transport

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.