Search Results
Overview
| Uniprot ID | A0A8L2R7D6 |
|---|---|
| Protein Name | MAGUK p55 subfamily member 2 |
| Gene Name | Mpp2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 368 | RMPPFRRKTLVLIGA |
Function
Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density. In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression. Seems to negatively regulate SRC function in epithelial cells
Protein Sequence
10
MACSPGSEAS
20
LEGISLGSSE
30
EAELRREAMQ
40
QVLDNLGSLP
50
NATGAAELDL
60
IFLRGIMESP
70
IVRSLAKAHE
80
RLEETKLEAV
90
RDNNLELVQE
100
ILRDLAELAE
110
QSSTAAELAR
120
ILQEPHFQSL
130
LETHDSVASK
140
TYETPPPSPG
150
LDPTFSNQPV
160
PPDAVRMVGI
170
RKTAGEHLGV
180
TFRVEGGELV
190
IARILHGGMV
200
AQQGLLHVGD
210
IIKEVNGQPV
220
GSDPRALQEL
230
LRSASGSVIL
240
KILPSYQEPH
250
LPRQVFVKCH
260
FDYDPARDSL
270
IPCKEAGLRF
280
NAGDLLQIVN
290
QDDANWWQAC
300
HVEGGSAGLI
310
PSQLLEEKRK
320
AFVKRDLELT
330
PTSGTLCGSL
340
SGKKKKRMMY
350
LTTKNAEFDR
360
HELLIYEEVA
370
RMPPFRRKTL
380
VLIGAQGVGR
390
RSLKNKLILW
400
DPDRYGTTVP
410
YTSRRPKDSE
420
REGQGYSFVS
430
RGEMEADIRA
440
GRYLEHGEYE
450
GNLYGTRIDS
460
IRGVVASGKV
470
CVLDVNPQAV
480
KVLRTAEFVP
490
YVVFIEAPDF
500
ETLRAMNRAA
510
LESGVSTKQL
520
TEADLRRTVE
530
ESSRIQRGYG
540
HYFDLSLVNS
550
NLERTFRELQ
560
TAMEKLRTEP
QWVPVSWVY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043226 | organelle |
| Molecular Function | GO:0098919 | structural constituent of postsynaptic density |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.