Search Results
Overview
| Uniprot ID | A0A8L2R8Y3 |
|---|---|
| Protein Name | Macrophage migration inhibitory factor |
| Gene Name | Mif |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 78 | AQNRNYSKLLCGLLS |
Function
Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity
Protein Sequence
10
MPMFIVNTNV
20
PRASVPEGFL
30
SELTQQLAQA
40
TGKPAQYIAV
50
HVVPDQLMTF
60
SGTSDPCALC
70
SLHSIGKIGG
80
AQNRNYSKLL
90
CGLLSDRLHI
100
SPDRVLRKNG
110
LIPPSVYLLR
120
VQREEQREHR
130
NFHSFPILLT
140
RQASSTAGAQ
150
EKQTAGKGVD
GKASRGG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0005125 | cytokine activity |
| Molecular Function | GO:0004167 | dopachrome isomerase activity |
| Molecular Function | GO:0050178 | phenylpyruvate tautomerase activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.