Overview
| Uniprot ID | A0A8L2UHV1 |
|---|
| Protein Name | 26S proteasome regulatory subunit 4 |
|---|
| Gene Name | Psmc1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 24 |
DDKDKKKKYEPPVPT |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides
Protein Sequence
10
MGQSQSGGHG
20
PGGGKKDDKD
30
KKKKYEPPVP
40
TRVGKKKKKT
50
KGPDAASKLP
60
LELGTEPRAL
70
RFLVTPHTQC
80
RLKLLKLERI
90
KDYLLMEEEF
100
IRNQEQMKPL
110
EEKQEEERSK
120
VDDLRGTPMS
130
VGTLEEIIDD
140
NHAIVSTSVG
150
SEHYVSILSF
160
VDKDLLEPGC
170
SVLLNHKVHA
180
VIGVLMDDTD
190
PLVTVMKVEK
200
APQETYADIG
210
GLDNQIQEIK
220
ESVELPLTHP
230
EYYEEMGIKP
240
PKGVILYGPP
250
GTGKTLLAKA
260
VANQTSATFL
270
RVVGSELIQK
280
YLGDGPKLVR
290
ELFRVAEEHA
300
PSIVFIDEID
310
AIGTKRYDSN
320
SGGEREIQRT
330
MLELLNQLDG
340
FDSRGDVKVI
350
MATNRIETLD
360
PALIRPGRID
370
RKIEFPLPDE
380
KTKKRIFQIH
390
TSRMTLADDV
400
TLDDLIMAKD
410
DLSGADIKAI
420
CTEAGLMALR
430
ERRMKVTNED
440
FKKSKENVLY
450
KKQEGTPEGL
YL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005838 |
proteasome regulatory particle |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.