Search Results
Overview
| Uniprot ID | A0A8L2UI37 |
|---|---|
| Protein Name | Heat shock protein 75 kDa, mitochondrial |
| Gene Name | Trap1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 137 | ARSLYSEKEVFIREL |
Function
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA
Protein Sequence
10
MTSLSRPCGR
20
PPRHSCWLFV
30
VLRNRSMARE
40
LRALLLWGRG
50
LQSALRAPAL
60
AGVRRGKPVL
70
HLQKTTVHFR
80
DPTQSLASGI
90
SAGQLYSTQA
100
AEDKKEEALH
110
SIISNTEAVQ
120
GSVSKHEFQA
130
ETKKLLDIVA
140
RSLYSEKEVF
150
IRELISNASD
160
ALEKLRHKRV
170
CEGQVLPEME
180
IHLQTDAEKG
190
TITIQDTGIG
200
MTKEELVSNL
210
GTIARSGSKA
220
FLEALQHQAE
230
TSSRIIGQFG
240
VGFYSAFMVA
250
DKVEVYSRPA
260
APESPGYQWL
270
SDGSGVFEIA
280
EASGVRPGTK
290
IIIHLKSDCK
300
DFANESRVQD
310
VVTKYSNFVS
320
FPLYLNGRRI
330
NTLQAIWMMD
340
PKDISEFQHE
350
EFYRYIAQAY
360
DKPRFILHYK
370
TDAPLNIRSI
380
FYVPEMKPSM
390
FDVSRELGSS
400
VALYSRKVLI
410
QTKATDILPK
420
WLRFVRGVVD
430
SEDIPLNLSR
440
ELLQESALIR
450
KLRDVLQQRL
460
IKFFIDQSKK
470
DAEKYAKFFE
480
DYGLFMREGI
490
VTTAEQDIKE
500
DIAKLLRYES
510
SALPAGQLTS
520
LSDYASRMQA
530
GTRNIYYLCA
540
PNRHLAEHSP
550
YYEAMKQKQT
560
EVLFCYEQFD
570
ELTLLHLREF
580
DKKKLISVET
590
DIVVDHYKEE
600
KFEDTSPAGE
610
RLSEKETEEL
620
MAWMRNALGS
630
RVTNVKVTFR
640
LDTHPAMVTV
650
LEMGAARHFL
660
RMQQLAKTQE
670
ERAQLLQPTL
680
EINPRHTLIK
690
KLNQLREREP
700
ELAQLLVDQI
710
YENAMIAAGL
720
VDDPRAMVGR
730
LNDLLVKALE
RH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0140662 | ATP-dependent protein folding chaperone |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:1901856 | negative regulation of cellular respiration |
| Biological Process | GO:0009386 | translational attenuation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.