Overview
| Uniprot ID | A0A8L2UJL1 |
|---|
| Protein Name | F-BAR domain only protein 2 |
|---|
| Gene Name | Fcho2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 435 |
RPKLTSGKLSGINEI |
Function
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor
Protein Sequence
10
MVKAYVGEKN
20
NGFDVLYHNM
30
KHGQISTKEL
40
ADFVRERATI
50
EEAYSRSMTK
60
LAKSASNYSQ
70
LGTFAPVWDV
80
FKTSTEKLAN
90
CHLDLVRKLQ
100
ELIKEVQKYG
110
EEQVKSHKKT
120
KEEVAGTLEA
130
VQAIQNITQA
140
LQKSKENYNA
150
KCVEQERLKK
160
EGATPREIEK
170
AAVKSKKATD
180
TYKLYVEKYA
190
LTKADFEQKM
200
TETAQKFQDI
210
EETHLIHIKE
220
IIGSLSNAIK
230
EIHLQIGQVH
240
EEFINNMANT
250
TIESLIQKFA
260
ESKGTGKERP
270
GLIEFEECDP
280
ASAVEGIKPR
290
KRKTFALPGI
300
IKKEKDAESV
310
ECPDADSLNI
320
PDVDEEGFSI
330
KPENHFYSSS
340
DSDSEDEEPK
350
RYRIEIKPVH
360
PNNVHHTMAS
370
LDELKVSIGN
380
ITLSPAVSVR
390
TNDLLAWDPL
400
FGSSLESSSA
410
PLTSSSSARP
420
TTPLSLGTIV
430
PPPRPASRPK
440
LTSGKLSGIN
450
EIPRPFSPPI
460
TSNTSPPPTA
470
PLARAESSSS
480
ISSSASLSAA
490
NTPTVGVSRG
500
PSPVSLGNQD
510
TLPVAIALTE
520
SVNAYFKGAD
530
PTKCIVKITG
540
DVTISFPSGI
550
IKVFTSNPSP
560
AVLCFRVKNI
570
SRLEQILPNS
580
QLVFSDPSQC
590
DSNTKDFWMN
600
MQAVTVYLKK
610
LSEQNPAASY
620
YNVDVLKYQV
630
SSNGIQSTPL
640
NLATYWKCSA
650
STTDLRVDYK
660
YNPEAMVAPS
670
VLSNIQVVVP
680
VDGGVTNMQS
690
LPPAIWNAEQ
700
MKAFWKLSGI
710
SEKSDSGGSG
720
SLRAKFDLSE
730
GPSKPATLAV
740
QFLSEGNTLS
750
GVDIELVGTG
760
YRLSLVKKRF
770
ATGKLACFEL
F
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005905 |
clathrin-coated pit |
| Cellular Component |
GO:0098793 |
presynapse |
| Biological Process |
GO:0048488 |
synaptic vesicle endocytosis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.