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Overview

Uniprot IDA0A8L2UMC0
Protein NameUnconventional myosin-XVIIIa
Gene NameMyo18a
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
719 AIFKHQLKGGTLQRS

Function

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking. Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages. Strongly enhances natural killer cell cytotoxicity

Protein Sequence

10 MFNLMKKDKD 20 KDGGRKEKKE 30 KKEKKERMSA 40 AELRSLEEMS 50 MRRGFFNLNR 60 SSKRESKTRL 70 EISNPIPIKV 80 ASGSDLHLTD 90 IDSDSNRGSI 100 ILDSGHLSTA 110 SSSDDLKGEE 120 GSFRGSVLQR 130 AAKFGSLAKQ 140 NSQMIVKRFS 150 FSQRSRDESA 160 SETSTPSEHS 170 AAPSPQVEVR 180 TLEGQLMQHS 190 GLGIPRPGPR 200 SRVPELVTKR 210 FPADLRLPAL 220 VPPPPPALRE 230 LELQRRPTGD 240 FGFSLRRTTM 250 LDRAPEGQAY 260 RRVVHFAEPG 270 AGTKDLALGL 280 VPGDRLVEIN 290 GQNVENKSRD 300 EIVEMIRQSG 310 DSVRLKVQPI 320 PELSELSRSW 330 LRTGEGHRRE 340 PTDAKTEEQI 350 AAEEAWYETE 360 KVWLVHRDGF 370 SLASQLKSEE 380 LSLPEGKVRV 390 KLDHDGAILD 400 VDEDDVEKAN 410 APSCDRLEDL 420 ASLVYLNESS 430 VLHTLRQRYG 440 ASLLHTYAGP 450 SLLVLSPRGA 460 PAVYSEKVMH 470 MFKGCRREDM 480 APHIYAVAQT 490 AYRAMLMSRQ 500 DQSIVLLGSS 510 GSGKTTSSQH 520 LVQYLATIAG 530 TSGNKVFSVE 540 KWQALATLLE 550 AFGNSPTIMN 560 GSATRFSQIL 570 SLDFDQAGQV 580 ASASVQTMLL 590 EKLRVARRPA 600 SEATFNVFYY 610 LLACGDSTLR 620 TELHLNHLAE 630 NNVFGIVPLS 640 KPEEKQRAAQ 650 QFSKLQTAMK 660 VLAISPEEQK 670 ACWLILASIY 680 HLGAAGATKA 690 VFSCGRKQFA 700 RHEWAQKAAY 710 LLGCSLEELS 720 SAIFKHQLKG 730 GTLQRSTSFR 740 QGPEESGLGE 750 GTGTKLSALE 760 CLEGMASGLY 770 SELFTLLISL 780 VNRALKSSQH 790 SLCSMMIVDT 800 PGFQNPEWGG 810 SARGASFEEL 820 CHNYAQDRLQ 830 KLFHERTFLQ 840 ELERYKEDNI 850 ELAFDDLEPV 860 TDDSVAAVDQ 870 ASHQSLVRSL 880 AHADEARGLL 890 WLLEEEALVP 900 GATEDTLLDR 910 LFSYYGPQEG 920 DKKGQSPLLR 930 SSKPRHFLLG 940 HSHGTNWVEY 950 NVTGWLNYTK 960 QNPATQNAPR 970 LLQDSQNSVV 980 ECLPSKRKAL 990 GSVLSSEKKK 1000 RKKKKKKKCP 1010 EVWPLPLWQD 1020 ALIDTIKRSK 1030 MHFVHCFLPV 1040 AEGWPGEPRS 1050 ASSRRVSSSS 1060 ELDLPPGDPC 1070 EAGLLQLDVS 1080 LLRAQLRGSR 1090 LLDAIRMYRQ 1100 GYPDHMVFSE 1110 FRRRFDVLAP 1120 HLTKKHGRNY 1130 IMVDEKRAVE 1140 ELLESLDLEK 1150 SSCCMGLSRV 1160 FFRAGTLARL 1170 EEQRDEETSR 1180 HLTLFQAACR 1190 GYLARQHFKK 1200 RKIQDLAIRC 1210 VQKNIKKNKG 1220 VKDWPWWKLF 1230 TTVRPLIQVQ 1240 LSEEQIRNKD 1250 EEIQQLRNKL 1260 EKVEKERNEL 1270 RLNSDRLETR 1280 ISELTSELTD 1290 ERNTGESASQ 1300 LLDAETAERL 1310 RTEKEMKELQ 1320 TQYDALKKQM 1330 EAMDMEVMEA 1340 RLIRAAEING 1350 EVDDDDAGGE 1360 WRLKYERAVR 1370 EVDFTKKRLQ 1380 QELEDKMEVE 1390 QQNRRQLERR 1400 LGDLQADSDE 1410 SQRALQQLKK 1420 KCQRLTAELQ 1430 DTKLHLEGQQ 1440 VRNHELEKKQ 1450 RRFDSELSQA 1460 HEETQREKLQ 1470 REKLQREKDM 1480 LLAEAFSLKQ 1490 QMEEKDLDIA 1500 GFTQKVVSLE 1510 AELQDISSQE 1520 SKDEASLAKV 1530 KKQLRDLEAK 1540 VKDQEEELDE 1550 QAGSIQMLEQ 1560 AKLRLEMEME 1570 RMRQTHSKEM 1580 ESRDEEVEEA 1590 RQSCQKKLRQ 1600 MEVQLEEEYE 1610 DKQKALREKR 1620 ELESKLSTLS 1630 DQVNQRDFES 1640 EKRLRKDLKR 1650 TKALLADAQI 1660 MLDHLKNNAP 1670 SKREIAQLKN 1680 QLEESEFTCA 1690 AAVKARKAME 1700 VEMEDLHLQI 1710 DDIAKAKTAL 1720 EEQLSRLQRE 1730 KNEIQNRLEE 1740 DQEDMNELMK 1750 KHKAAVAQAS 1760 RDMAQMNDLQ 1770 AQLEESNKEK 1780 QELQEKLQAL 1790 QSQVEFLEQS 1800 MVDKSLVSRQ 1810 EAKIRELETR 1820 LEFEKTQVKR 1830 LESMASRLKE 1840 NMEKLTEERD 1850 QRAAAENREK 1860 EQNKRLQRQL 1870 RDTKEEMSEL 1880 ARKEAEASRK 1890 KHELEMDLES 1900 LEAANQSLQA 1910 DLKLAFKRIG 1920 DLQAAIEDEM 1930 ESDENEDLIN 1940 SLQDMVTKYQ 1950 KRKNKLEGDS 1960 DVDSELEDRV 1970 DGVKSWLSKN 1980 KGPSKAPSDD 1990 GSLKSSSPTS 2000 HWKSLAPDLS 2010 DDEHDPVDSI 2020 SRPRFSHNYL 2030 SDSDTEAKLT ETNA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005815 microtubule organizing center
Cellular Component GO:0016459 myosin complex
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0003774 cytoskeletal motor activity
Biological Process GO:1903028 positive regulation of opsonization
Biological Process GO:0043030 regulation of macrophage activation

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.