Overview
| Uniprot ID | A0A8L2UMC0 |
| Protein Name | Unconventional myosin-XVIIIa |
| Gene Name | Myo18a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 719 |
AIFKHQLKGGTLQRS |
Function
May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking. Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages. Strongly enhances natural killer cell cytotoxicity
Protein Sequence
10
MFNLMKKDKD
20
KDGGRKEKKE
30
KKEKKERMSA
40
AELRSLEEMS
50
MRRGFFNLNR
60
SSKRESKTRL
70
EISNPIPIKV
80
ASGSDLHLTD
90
IDSDSNRGSI
100
ILDSGHLSTA
110
SSSDDLKGEE
120
GSFRGSVLQR
130
AAKFGSLAKQ
140
NSQMIVKRFS
150
FSQRSRDESA
160
SETSTPSEHS
170
AAPSPQVEVR
180
TLEGQLMQHS
190
GLGIPRPGPR
200
SRVPELVTKR
210
FPADLRLPAL
220
VPPPPPALRE
230
LELQRRPTGD
240
FGFSLRRTTM
250
LDRAPEGQAY
260
RRVVHFAEPG
270
AGTKDLALGL
280
VPGDRLVEIN
290
GQNVENKSRD
300
EIVEMIRQSG
310
DSVRLKVQPI
320
PELSELSRSW
330
LRTGEGHRRE
340
PTDAKTEEQI
350
AAEEAWYETE
360
KVWLVHRDGF
370
SLASQLKSEE
380
LSLPEGKVRV
390
KLDHDGAILD
400
VDEDDVEKAN
410
APSCDRLEDL
420
ASLVYLNESS
430
VLHTLRQRYG
440
ASLLHTYAGP
450
SLLVLSPRGA
460
PAVYSEKVMH
470
MFKGCRREDM
480
APHIYAVAQT
490
AYRAMLMSRQ
500
DQSIVLLGSS
510
GSGKTTSSQH
520
LVQYLATIAG
530
TSGNKVFSVE
540
KWQALATLLE
550
AFGNSPTIMN
560
GSATRFSQIL
570
SLDFDQAGQV
580
ASASVQTMLL
590
EKLRVARRPA
600
SEATFNVFYY
610
LLACGDSTLR
620
TELHLNHLAE
630
NNVFGIVPLS
640
KPEEKQRAAQ
650
QFSKLQTAMK
660
VLAISPEEQK
670
ACWLILASIY
680
HLGAAGATKA
690
VFSCGRKQFA
700
RHEWAQKAAY
710
LLGCSLEELS
720
SAIFKHQLKG
730
GTLQRSTSFR
740
QGPEESGLGE
750
GTGTKLSALE
760
CLEGMASGLY
770
SELFTLLISL
780
VNRALKSSQH
790
SLCSMMIVDT
800
PGFQNPEWGG
810
SARGASFEEL
820
CHNYAQDRLQ
830
KLFHERTFLQ
840
ELERYKEDNI
850
ELAFDDLEPV
860
TDDSVAAVDQ
870
ASHQSLVRSL
880
AHADEARGLL
890
WLLEEEALVP
900
GATEDTLLDR
910
LFSYYGPQEG
920
DKKGQSPLLR
930
SSKPRHFLLG
940
HSHGTNWVEY
950
NVTGWLNYTK
960
QNPATQNAPR
970
LLQDSQNSVV
980
ECLPSKRKAL
990
GSVLSSEKKK
1000
RKKKKKKKCP
1010
EVWPLPLWQD
1020
ALIDTIKRSK
1030
MHFVHCFLPV
1040
AEGWPGEPRS
1050
ASSRRVSSSS
1060
ELDLPPGDPC
1070
EAGLLQLDVS
1080
LLRAQLRGSR
1090
LLDAIRMYRQ
1100
GYPDHMVFSE
1110
FRRRFDVLAP
1120
HLTKKHGRNY
1130
IMVDEKRAVE
1140
ELLESLDLEK
1150
SSCCMGLSRV
1160
FFRAGTLARL
1170
EEQRDEETSR
1180
HLTLFQAACR
1190
GYLARQHFKK
1200
RKIQDLAIRC
1210
VQKNIKKNKG
1220
VKDWPWWKLF
1230
TTVRPLIQVQ
1240
LSEEQIRNKD
1250
EEIQQLRNKL
1260
EKVEKERNEL
1270
RLNSDRLETR
1280
ISELTSELTD
1290
ERNTGESASQ
1300
LLDAETAERL
1310
RTEKEMKELQ
1320
TQYDALKKQM
1330
EAMDMEVMEA
1340
RLIRAAEING
1350
EVDDDDAGGE
1360
WRLKYERAVR
1370
EVDFTKKRLQ
1380
QELEDKMEVE
1390
QQNRRQLERR
1400
LGDLQADSDE
1410
SQRALQQLKK
1420
KCQRLTAELQ
1430
DTKLHLEGQQ
1440
VRNHELEKKQ
1450
RRFDSELSQA
1460
HEETQREKLQ
1470
REKLQREKDM
1480
LLAEAFSLKQ
1490
QMEEKDLDIA
1500
GFTQKVVSLE
1510
AELQDISSQE
1520
SKDEASLAKV
1530
KKQLRDLEAK
1540
VKDQEEELDE
1550
QAGSIQMLEQ
1560
AKLRLEMEME
1570
RMRQTHSKEM
1580
ESRDEEVEEA
1590
RQSCQKKLRQ
1600
MEVQLEEEYE
1610
DKQKALREKR
1620
ELESKLSTLS
1630
DQVNQRDFES
1640
EKRLRKDLKR
1650
TKALLADAQI
1660
MLDHLKNNAP
1670
SKREIAQLKN
1680
QLEESEFTCA
1690
AAVKARKAME
1700
VEMEDLHLQI
1710
DDIAKAKTAL
1720
EEQLSRLQRE
1730
KNEIQNRLEE
1740
DQEDMNELMK
1750
KHKAAVAQAS
1760
RDMAQMNDLQ
1770
AQLEESNKEK
1780
QELQEKLQAL
1790
QSQVEFLEQS
1800
MVDKSLVSRQ
1810
EAKIRELETR
1820
LEFEKTQVKR
1830
LESMASRLKE
1840
NMEKLTEERD
1850
QRAAAENREK
1860
EQNKRLQRQL
1870
RDTKEEMSEL
1880
ARKEAEASRK
1890
KHELEMDLES
1900
LEAANQSLQA
1910
DLKLAFKRIG
1920
DLQAAIEDEM
1930
ESDENEDLIN
1940
SLQDMVTKYQ
1950
KRKNKLEGDS
1960
DVDSELEDRV
1970
DGVKSWLSKN
1980
KGPSKAPSDD
1990
GSLKSSSPTS
2000
HWKSLAPDLS
2010
DDEHDPVDSI
2020
SRPRFSHNYL
2030
SDSDTEAKLT
ETNA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0005815 |
microtubule organizing center |
| Cellular Component |
GO:0016459 |
myosin complex |
| Molecular Function |
GO:0003779 |
actin binding |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0003774 |
cytoskeletal motor activity |
| Biological Process |
GO:1903028 |
positive regulation of opsonization |
| Biological Process |
GO:0043030 |
regulation of macrophage activation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.