Overview
| Uniprot ID | A0A8L2UNG3 |
|---|
| Protein Name | Aquaporin-4 |
|---|
| Gene Name | Aqp4 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 342 |
RLKEAFSKAAQQTKG |
| 348 |
SKAAQQTKGSYMEVE |
| 385 |
IDRGDEKKGKDSSGE |
| 387 |
RGDEKKGKDSSGEVL |
Function
Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability
Protein Sequence
10
MSRLQRVLEG
20
GWPFPGPPLL
30
GAVLPQQGLF
40
PTHPAPFTSC
50
SVPSSFFPIK
60
PQKTAPVIAP
70
CPSATWLQPW
80
TAGEFRSDCP
90
HSFSIKCGPP
100
CSRESIMVAF
110
KGVWTQAFWK
120
AVTAEFLAML
130
IFVLLSVGST
140
INWGGSENPL
150
PVDMVLISLC
160
FGLSIATMVQ
170
CFGHISGGHI
180
NPAVTVAMVC
190
TRKISIAKSV
200
FYITAQCLGA
210
IIGAGILYLV
220
TPPSVVGGLG
230
VTTVHGNLTA
240
GHGLLVELII
250
TFQLVFTIFA
260
SCDSKRTDVT
270
GSVALAIGFS
280
VAIGHLFAIN
290
YTGASMNPAR
300
SFGPAVIMGN
310
WENHWIYWVG
320
PIIGAVLAGA
330
LYEYVFCPDV
340
ELKRRLKEAF
350
SKAAQQTKGS
360
YMEVEDNRSQ
370
VETEDLILKP
380
GVVHVIDIDR
390
GDEKKGKDSS
GEVLSSV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0097450 |
astrocyte end-foot |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0030054 |
cell junction |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0009897 |
external side of plasma membrane |
| Cellular Component |
GO:0042383 |
sarcolemma |
| Molecular Function |
GO:0015250 |
water channel activity |
| Biological Process |
GO:0071346 |
cellular response to type II interferon |
| Biological Process |
GO:0009992 |
intracellular water homeostasis |
| Biological Process |
GO:0050891 |
multicellular organismal-level water homeostasis |
| Biological Process |
GO:0051289 |
protein homotetramerization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.